doi:10.3969/j.issn.1673-8640.2021.09.008

Abstract

CLC Number:

R446.62

Figures/Tables 5

References 11

[1]	ATASHZAR M R, BAHARLOU R, KARAMI J, et al. Cancer stem cells:a review from origin to therapeutic implications[J]. J Cell Physiol, 2020, 235(2):790-803. DOI URL
[2]	PAN Y, MA S, CAO K, et al. Therapeutic approaches targeting cancer stem cells[J]. J Cancer Res Ther, 2018, 14(7):1469-1475. DOI URL
[3]	GOPALAN V, ISLAM F, LAM A K. Surface markers for the identification of cancer stem cells[J]. Methods Mol Biol, 2018, 1692:17-29.
[4]	赵景锋, 龚代平, 卿松, 等. 结肠癌干细胞的研究进展与在临床治疗中的意义[J]. 重庆医学, 2014, 43(23):3096-3098.
[5]	林家耀, 张志明, 刘剑勇, 等. 肝细胞性肝癌组织CD133+细胞肿瘤干细胞特性的研究[J]. 中华肿瘤防治杂志, 2016, 23(4):223-227.
[6]	覃宇奇, 覃冠平, 蓝川, 等. 乙醛脱氢酶1、CD133在鼻咽癌组织中的表达及临床意义[J]. 疑难病杂志, 2015, 14(6):590-592.
[7]	谷化平, 黄勇, 尚培中. 干细胞转录因子Oct4和CD133蛋白在肝外胆管癌组织中的表达及临床意义[J]. 中国现代普通外科进展, 2014, 17(2):112-115.
[8]	张泽峰, 高峰, 王涛, 等. CD133蛋白在非小细胞肺癌组织中的表达及其与临床病理参数及预后的关系[J]. 现代生物医学进展, 2016, 16(28):5575-5578.
[9]	唐治蓉, 龙琼先, 刘欣雅, 等. CD133及CD44在肺癌组织中表达及其与临床病理学特征和预后的关系[J]. 中国实验诊断学, 2019, 23(12):2108-2112.
[10]	MELE L, LICCARDO D, TIRINO V. Evaluation and isolation of cancer stem cells using ALDH activity assay[J]. Methods Mol Biol, 2018, 1692:43-48.
[11]	杨丽青, 刘威. 乙醛脱氢酶1在乳腺癌转移淋巴结中的表达及其临床意义[J]. 新乡医学院学报, 2019, 36(10):945-948.

组别	例数	WBC计数/（×10⁹/L）	LYMPH#/（×10⁹/L）	ALT/（U/L）	AST/（U/L）	PA/（g/L）	AFP/（ng/mL）
正常对照组	70	5.39±1.02	1.63±0.51	28.40±5.60	29.23±4.94	248.29±19.84	5.78±1.42
肝硬化组	70	5.19±0.92	1.43±0.21^*	48.23±15.94^*	58.33±17.94^*	88.29±11.64^*	23.20±11.51^*
HCC组	70	5.09±0.82	1.18±0.31^*#	52.13±15.34^*	62.53±15.70^*	118.09±16.64^*#	68.43±20.45^*#
统计值		1.915	25.729	65.298	116.522	1 886.345	397.320
P值		0.150	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	WBC计数/（×10⁹/L）	LYMPH#/（×10⁹/L）	ALT/（U/L）	AST/（U/L）	PA/（g/L）	AFP/（ng/mL）
正常对照组	70	5.39±1.02	1.63±0.51	28.40±5.60	29.23±4.94	248.29±19.84	5.78±1.42
肝硬化组	70	5.19±0.92	1.43±0.21^*	48.23±15.94^*	58.33±17.94^*	88.29±11.64^*	23.20±11.51^*
HCC组	70	5.09±0.82	1.18±0.31^*#	52.13±15.34^*	62.53±15.70^*	118.09±16.64^*#	68.43±20.45^*#
统计值		1.915	25.729	65.298	116.522	1 886.345	397.320
P值		0.150	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	CD133%/%	ALDH1/（ng/mL）
HCC组	70	0.79±0.02	31.55±5.42
肝硬化组	70	0.03±0.01^*	4.92±1.31^*
正常对照组	70	0.02±0.01^*	4.11±0.76^*
F值		68 285.00	1 616.57
P值		<0.001	<0.001

组别	例数	CD133%/%	ALDH1/（ng/mL）
HCC组	70	0.79±0.02	31.55±5.42
肝硬化组	70	0.03±0.01^*	4.92±1.31^*
正常对照组	70	0.02±0.01^*	4.11±0.76^*
F值		68 285.00	1 616.57
P值		<0.001	<0.001

项目	例数	CD133%/%	ALDH1/（ng/mL）
年龄
>35岁	34	0.79±0.04	32.95±6.42
≤35岁	36	0.78±0.05	32.75±5.94
t值		0.921	0.135
P值		0.360	0.893
性别
男性	32	0.80±0.03	33.10±5.40
女性	38	0.81±0.01	32.86±4.94
t值		-1.933	0.194
P值		0.057	0.847
肿瘤细胞分化程度
低	20	0.71±0.04	19.08±5.10
中	26	0.88±0.05	26.18±5.21
高	24	0.95±0.03	38.23±6.54
F值		192.670	64.987
P值		<0.001	<0.001
肿瘤大小
>3 cm	40	0.85±0.07	34.19±5.53
≤3 cm	30	0.71±0.05	33.90±4.34
t值		9.310	0.237
P值		<0.001	0.813
TNM分期
Ⅰ~Ⅱ期	32	0.66±0.04	25.17±5.15
Ⅲ~Ⅳ期	38	0.98±0.03	37.78±4.58
t值		-38.198	-10.841
P值		<0.001	<0.001

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 5

References 11

Related Articles 15

Recommended Articles

Metrics

[1]	TANG Qingqin, QIAO Longwei, YIN Jingping, ZHANG Sheng, FENG Bin, LIANG Yuting. Correlation of peripheral blood monocyte count and serum anti-phospholipase A2 receptor antibody in patients with nephrotic syndrome [J]. Laboratory Medicine, 2023, 38(7): 647-652.
[2]	WANG Haiping, LI He. BISAP score combined with serum sRAGE for predicting hyperlipidemic acute pancreatitis severity and short-term prognosis [J]. Laboratory Medicine, 2023, 38(7): 653-658.
[3]	WU Jie, LI Zenghe, CHEN Baorong, KONG Xujing. Establishment of traceable steroid hormone standard curve for dried blood spot samples [J]. Laboratory Medicine, 2023, 38(5): 489-493.
[4]	. [J]. Laboratory Medicine, 2023, 38(3): 291-293.
[5]	. [J]. Laboratory Medicine, 2023, 38(1): 100-102.
[6]	. [J]. Laboratory Medicine, 2022, 37(9): 892-893.
[7]	SUN Xiaodan, LIU Yiwen, HE Yiqing, DU Yan, ZHANG Guoliang, GAO Feng, YANG Cuixia. Research progress on the role of estrogen receptor in osteosarcoma [J]. Laboratory Medicine, 2022, 37(4): 313-318.
[8]	SUN Xiaodan, XU Jing, LIU Yiwen, HE Yiqing, DU Yan, ZHANG Guoliang, GAO Feng, YANG Cuixia. Inhibitory effects of antiestrogen on the proliferation and CCL2 expression of osteosarcoma cells [J]. Laboratory Medicine, 2022, 37(4): 319-324.
[9]	CHEN Si, LIU Hua, LIU Yiwen, HE Yiqing, ZHANG Guoliang, YANG Cuixia, DU Yan, GAO Feng. Clinical significance of combined determination of serum HER-2 and CD44 in colorectal cancer [J]. Laboratory Medicine, 2022, 37(4): 336-341.
[10]	ZHAO Mingna, ZHANG Chenzi, HONG Qiushuang, LOU Jiatao. Mechanism of IL-8/miR-182 positive feedback regulatory axis in non-small cell lung cancer [J]. Laboratory Medicine, 2022, 37(4): 349-355.
[11]	ZHANG Zhibin, YANG Wanyong, RUAN Fuwang, WEN Qinghui. Roles of total IgE,sIgE and 25（OH）D in the evaluation of infant atopic dermatitis [J]. Laboratory Medicine, 2022, 37(3): 217-220.
[12]	. [J]. Laboratory Medicine, 2021, 36(12): 1264-1266.
[13]	QIU Fang, ZHU Ping, JIANG Peng, WANG Chan. Relation between anti-gp210 antibody,anti-sp100 antibody and ALBI score in patients with primary biliary cholangitis [J]. Laboratory Medicine, 2021, 36(11): 1106-1109.
[14]	LIU Yang, ZHANG Zhiping, PENG Daorong, SONG Liuwei, GE Shengxiang, HAO Xiaoke, LIU Jiayun. Establishment and performance evaluation of chemiluminescent microparticle immunoassay for the determination of high concentration HbsAg [J]. Laboratory Medicine, 2020, 35(10): 1056-1061.
[15]	. [J]. Laboratory Medicine, 2020, 35(9): 957-959.