Abstract:

Objective To study the role of serum amyloid A（SAA）,C-reactive protein（CRP） and erythrocyte sedimentation rate（ESR） combined determination in the diagnosis of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods A total of 100 AECOPD patients were enrolled and classified into AECOPDⅠ group （44 cases） and AECOPDⅡ/Ⅲ group （56 cases） according to the severity of AECOPD. Totally,50 healthy subjects were enrolled as control group. The levels of SAA,CRP and ESR were determined. Logistic regression and receiver operating characteristic（ROC） curve were used to analyze the diagnosis efficiency of SAA,CRP and ESR single determinations and combined determination. Results The levels of SAA,CRP and ESR in control,AECOPDⅠ and AECOPD Ⅱ/Ⅲ groups increased in turn （P<0.05）. ROC curve analysis showed that the area under curve （AUC） of SAA,CRP and ESR single determinations were 0.835,0.906 and 0.873,the sensitivities were 79.98%,80.54% and 83.54%,the specificities were 85.65%,87.78% and 78.76%,the accuracies were 86.76%,79.76% and 82.13%,and the Youden indices were 0.66,0.68 and 0.62, respectively. The AUC of SAA,CRP and ESR combined determination for the diagnosis of AECOPD was 0.949,the sensitivity was 96.65%,the specificity was 92.35%,the accuracy was 90.34%,and the Youden index was 0.89. Conclusions SAA,CRP and ESR combined determination has high sensitivity and specificity for the diagnosis of AECOPD.

Key words: Amyloid A, C-reactive protein, Erythrocyte sedimentation rate, Acute exacerbation of chronic obstructive pulmonary disease