Abstract:

Objective To investigate the correlations of red blood cell distribution width （RDW） and related inflammation factors with disease activity in patients with rheumatoid arthritis （RA）. Methods A total of 110 patients with RA,50 patients with gout and 50 healthy subjects were enrolled. RDW,erythrocyte sedimentation rate （ESR）,C-reactive protein（CRP）,rheumatoid factor（RF） and anti-cyclic citrullinated peptide（CCP） antibody were determined. According to disease activity score（DAS）28 levels,RA patients were classified into 2 groups,high-active group（DAS 28>5.1,60 cases） and low-active group （DAS 28 2.6-3.2,50 cases）. Results RDW,CRP,ESR,anti-CCP antibody and RF were increased gradually in healthy control,gout,RA high-active and low-active groups （P<0.01）. The rate of bone erosion in patients with RA was 60.9%. RDW,ESR and CRP in patients with bone erosion was higher than those in patients without bone erosion （P<0.01）. High titers of anti-CCP antibody （>300 RU/mL） and RF （>200 IU/mL） in RA group were also related with high bone erosion rates. Conclusions RDW and high titers of anti-CCP antibody and RF can be used as parameters for evaluating disease activity of RA.

Key words: Red blood cell distribution width, Inflammation factors, Rheumatoid arthritis, Activity