Research progress in circulating microparticles

doi:10.3969/j.issn.1673-8640.2017.011.027

Abstract

Abstract:

Microparticles（MP） are vesicles that release from active or apoptosis cells,with size ranging from 0.1 μm to 1.0 μm. MP are capable of transferring peptides,proteins,lipid components,DNA and mRNA. Methods of MP determination are various,and the most common approach is flow cytometry. As the study of MP is deeper and deeper,it is found that MP are relevant with the development of cancers,infections and other diseases,with large diagnostic and therapeutic potential.

Key words: Microparticle, Flow cytometry, Disease, Diagnosis

CLC Number:

R446.62

ZHANG Yuncong, CUI Chanjuan, QIAO Rui, ZHANG Jie. Research progress in circulating microparticles[J]. Laboratory Medicine, 2017, 32(11): 1059-1064.

Figures/Tables 1

References 41

[1]	BREEN K A,SANCHEZ K,KIRKMAN N,et al.Endothelial and platelet microparticles in patients with antiphospholipid antibodies[J]. Thromb Res,2015,135(2):368-374.
[2]	NICCOLAI E,SQUATRITO D,EMMI G,et al.A new cytofluorimetric approach to evaluate the circulating microparticles in subjects with antiphospholipid antibodies[J]. Thromb Res,2015,136(6):1252-1258.
[3]	VIKERFORS A,MOBARREZ F,BREMME K,et al.Studies of microparticles in patients with the antiphospholipid syndrome(APS)[J]. Lupus,2012,21(7):802-805.
[4]	BEVERS E M,COMFURIUS P,VAN RIJN J L,et al. Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets[J]. Eur J Biochem,1982,122(2):429-436.
[5]	ZWAAL R F,BEVERS E M.Platelet phospholipid asymmetry and its significance in hemostasis[J]. Subcell Biochem,1983,9:299-334.
[6]	VAN DIEIJEN G,TANS G,ROSING J,et al.The role of phospholipid and factor Ⅷa in the activation of bovine factor X[J]. J Biol Chem,1981,256(7):3433-3442.
[7]	ROSING J,SPEIJER H,ZWAAL R F.Prothrombin activation on phospholipid membranes with positive electrostatic potential[J]. Biochemistry,1988,27(1):8-11.
[8]	FOX J E,AUSTIN C D,BOYLES J K,et al.Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane[J]. J Cell Biol,1990,111(2):483-493.
[9]	DIAZ C,SCHROIT A J.Role of translocases in the generation of phosphatidylserine asymmetry[J]. J Membr Biol,1996,151(1):1-9.
[10]	CONNOR J,PAK C H,ZWAAL R F,et al.Bidirectional transbilayer movement of phospholipid analogs in human red blood cells. Evidence for an ATP-dependent and protein-mediated process[J]. J Biol Chem,1992,267(27):19412-19417.
[11]	MCLAUGHLIN P J,GOOCH J T,MANNHERZ H G,et al.Structure of gelsolin segment 1-actin complex and the mechanism of filament severing[J]. Nature,1993,364(6439):685-692.
[12]	ZWAAL R F,COMFURIUS P,BEVERS E M.Mechanism and function of changes in membrane-phospholipid asymmetry in platelets and erythrocytes[J]. Biochem Soc Trans,1993,21(2):248-253.
[13]	MURPHY W G,MOORE J C,KELTON J G.Calcium-dependent cysteine protease activity in the sera of patients with thrombotic thrombocytopenic purpura[J]. Blood,1987,70(5):1683-1687.
[14]	KELTON J G,WARKENTIN T E,HAYWARD C P,et al.Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles[J]. Blood,1992,80(9):2246-2251.
[15]	BARTENEVA N S,FASLER-KAN E,BERNIMOULIN M,et al.Circulating microparticles:square the circle[J]. BMC Cell Biol,2013,14:23.
[16]	HESS C,SADALLAH S,HEFTI A,et al.Ectosomes released by human neutrophils are specialized functional units[J]. J Immunol,1999,163(8):4564-4573.
[17]	TILLEY R E,HOLSCHER T,BELANI R,et al.Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients[J]. Thromb Res,2008,122(5):604-609.
[18]	ROOD I M,DEEGENS J K,MERCHANT M L,et al.Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome[J]. Kidney Int,2010,78(8):810-816.
[19]	DUARTE T A,NORONHA-DUTRA A A,NERY J S,et al. Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation[J]. Tuberculosis(Edinb),2012,92(3):218-225.
[20]	WITEK R P,YANG L,LIU R,et al. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells[J]. Gastroenterology,2009,136(1):320-330.e2.
[21]	PORRO C,LEPORE S,TROTTA T,et al.Isolation and characterization of microparticles in sputum from cystic fibrosis patients[J]. Respir Res,2010,11:94.
[22]	PHILIPPOVA M,SUTER Y,TOGGWEILER S,et al.T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis[J]. Eur Heart J,2011,32(6):760-771.
[23]	MRVAR-BRECKO A,SUSTAR V,JANSA V,et al.Isolated microvesicles from peripheral blood and body fluids as observed by scanning electron microscope[J]. Blood Cells Mol Dis,2010,44(4):307-312.
[24]	BURGER D,MONTEZANO A C,NISHIGAKI N,et al.Endothelial microparticle formation by angiotensin Ⅱ is mediated via Ang Ⅱ receptor type Ⅰ/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts[J]. Arterioscler Thromb Vasc Biol,2011,31(8):1898-1907.
[25]	DISTLER J H,JÜNGEL A,HUBER L C,et al. The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles[J]. Proc Natl Acad Sci U S A,2005,102(8):2892-2897.
[26]	LIMA L G,CHAMMAS R,MONTEIRO R Q,et al.Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner[J]. Cancer Lett,2009,283(2):168-175.
[27]	JY W,HORSTMAN L L,JIMENEZ J J,et al.Measuring circulating cell-derived microparticles[J]. J Thromb Haemost,2004,2(10):1842-1851.
[28]	MIYAMOTO S,MARCINKIEWICZ C,EDMUNDS L H,et al.Measurement of platelet microparticles during cardiopulmonary bypass by means of captured ELISA for GPⅡb/Ⅲa[J]. Thromb Haemost,1998,80(2):225-230.
[29]	ABRAMS C S,ELLISON N,BUDZYNSKI A Z,et al.Direct detection of activated platelets and platelet-derived microparticles in humans[J]. Blood,1990,75(1):128-138.
[30]	SIMS P J,WIEDMER T,ESMON C T,et al.Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome:an isolated defect in platelet procoagulant activity[J]. J Biol Chem,1989,264(29):17049-17057.
[31]	REN J G,ZHANG W,LIU B,et al.Clinical significance and roles in angiogenesis of circulating microparticles in oral cancer[J]. J Dent Res,2016,95(8):860-867.
[32]	WILLMS A,MÜLLER C,JULICH H,et al. Tumour-associated circulating microparticles:a novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial neoplasia[J]. Oncotarget,2016,7(21):30867-30875.
[33]	HU S S,ZHANG H G,ZHANG Q J,et al.Small-size cirulating endothelial microparticles in coronary artery disease[J]. PLos One,2014,9(8):e104528.
[34]	VION A C,RAMKHELAWON B,LOYER X,et al.Shear stress regulates endothelial microparticle release[J]. Circ Res,2013,112(10):1323-1333.
[35]	BURGER D,TURNER M,MUNKONDA M N,et al.Endothelial microparticle-derived reactive oxygen species:role in endothelial signaling and vascular function[J]. Oxid Med Cell Longev,2016,2016:5047954.
[36]	TZEMOS N,LYSEGGEN E,SILVERSIDES C,et al.Endothelial function, carotid-femoral stiffness,and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta[J]. J Am Coll Cardiol,2010,55(7):660-668.
[37]	ALEGRET J M,MARTÍNEZ-MICAELO N,ARAGONÈS G,et al. Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation[J]. Int J Cardiol,2016,217:35-41.
[38]	OEHMCKE S,MÖRGELIN M,MALMSTRÖM J,et al. Stimulation of blood mononuclear cells with bacterial virulence factors leads to the release of pro-coagulant and pro-inflammatory microparticles[J]. Cell Microbiol,2012,14(1):107-119.
[39]	WOEI-A-JIN F J,VAN DER STARRE W E,TESSELAAR M E,et al. Procoagulant tissue factor activity on microparticles is associated with disease severity and bacteremia in febrile urinary tract infections[J]. Thromb Res,2014,133(5):799-803.
[40]	HARE N J,CHAN B,CHAN E,et al.Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type Ⅰ interferon inducible proteins including ISG15[J]. Proteomics,2015,15(17):3020-3029.
[41]	WALTERS S B,KIECKBUSCH J,NAGALINGAM G,et al.Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration[J]. J Immunol,2013,190(2):669-677.