Clinical research on the correlationship of different cytokines and proteins with pregnancy induced hypertension syndrome

doi:10.3969/j.issn.1673-8640.2014.08.009

Abstract

Abstract: Objective To investigate the clinical significance of serum tumor necrosis factor-alpha(TNF-α), interleukin 12(IL-12), interleukin 4(IL-4), immunoglobulin (Ig)G, IgA, IgM, complement (C)3, C4 and C-reactive protein(CRP)in the diagnosis of pregnancy induced hypertension syndrome and the change regularity in different degrees of pregnancy induced hypertension syndrome. Methods The serum samples were collected from 114 patients with pregnancy induced hypertension syndrome and 93 healthy pregnant women. The levels of TNF-α, IL-12 and IL-4 were determined by enzyme-linked immunosorbent assay(ELISA), the levels of IgG, IgA, IgM, C3, C4 and CRP were determined by immunonephelometry. Results The levels of serum TNF-α, IL-12 and CRP in pregnancy induced hypertension sydrome group were higher significantly than those in healthy pregnant group (P<0.001). The levels of serum IL-4, IgG, IgM, C3 and C4 in pregnancy induced hypertension syndrome group were lower than those in healthy pregnant group (P<0.001). The levels of serum TNF-α, IL-12 and CRP in prophase of heavy degree eclampsia were higher significantly than in prophase of light degree eclampsia (P<0.05, 0.001 and 0.001), and the levels of serum IL-4, IgG, C3 and C4 were lower (P<0.05). There was a positive correlation of serum CRP with IL-12 and TNF-α among pregnancy induced hypertension syndrome, prophase of light degree eclampsia, prophase of heavy degree eclampsia and healthy pregnant groups (P<0.05). There was a negative correlation of serum TNF-α with C3 and C4 among pregnancy induced hepertension sydrome, prophase of light degree eclampsia, prophase of heavy degree eclampsia and healthy pregnant groups, respectively (P<0.05). Conclusions The levels of serum TNF-α, IL-12, IL-4, IgG, IgM, C3, C4 and CRP are different-degree abnormal in pregnancy induced hypertension syndrome group, and the levels of serum IL-12, IL-4, IgG, C3, C4 and CRP reflect the severity degree of pregnancy induced hypertension syndrome, and can be effective markers for judging patient's conditions.

Key words: Tumor necrosis factor-alpha, Interleukin 12, Interleukin 4, Immunoglobulin, Complement, C-reactive protein, Pregnancy induced hypertension syndrome

CLC Number:

R446.1

HAO Dianjin, LI Yazhuo, SUN Xin, LI Hongchen, ZHANG Xiujun. Clinical research on the correlationship of different cytokines and proteins with pregnancy induced hypertension syndrome[J]. , 2014, 29(8): 822-825.

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