Mast cells exerting protumorigenic role in the early phase of gastric carcinoma and its biological significance

doi:10.3969/j.issn.1673-8640.2013.01.016

Abstract

Abstract: Objective　To investigate the correlation of mast cell with tumorigenesis and survival time through analyzing the mast cell counts in the tissues of gastric carcinoma，precancerous lesions of gastric carcinoma and benign gastric lesions. Methods　The pathological and follow-up data of 59 patients with gastric carcinoma，40 patients with precancerous lesions of gastric carcinoma and 39 patients with benign gastric lesions were analyzed retrospectively. The mast cell specific tryptase was labeled by immunohistochemistry. The counts and distribution of mast cells in the tissues of gastric carcinoma（high，middle and low differentiation）were analyzed. The expression in the tissues of gastric carcinoma was compared with those in the tissues of precancerous lesions of gastric carcinoma and benign gastric lesions，and the correlation of mast cell with pathological data and survival time was analyzed simultaneously. Results　The mast cell counts were higher in the tissues of gastric carcinoma and precancerous lesions of gastric carcinoma than those of benign gastric lesions （P＜0.05 and P＜0.05），and the mast cell counts in the tissues of precanerous lesions of gastric carcinoma were higher than those of gastric carcinoma （P＜0.05). According to the medians of mast cell counts（28.43），the results between gastric carcinoma group and precancerous lesions of gastric carcinoma group were compared，and the survival times of high-levle and low-level mast cell counts in gastric carcinoma and precancerous lesions of gastric carcinoma groups had no statistical significance （P＞0.05 and P＞0.05). There were correlations of mast cell counts with Helicobacter pylori and Ki-67 expression （P＜0.05 and P＜0.05). Conclusions　The varied mast cell counts show that mast cells correlate the protumorigenesis，especially Helicobacter pylori induced gastric carcinoma. The correlation of mast cell and Ki-67 shows mast cell exert tumor proliferation and progression，but there is no correlation with the degree of differentiation. There is no obvious correlation of mast cell with survival time.

Key words: Mast cell, Gastric cancer, Precancerous lesion of gastric carcinoma, Helicobacter pylori, Survival time

LIU Yanan，LIN Lihui，WANG Juan，LI Jia，PENG Xia，XIAO Hui，LI Fei，DAI Huirong，LI Li. Mast cells exerting protumorigenic role in the early phase of gastric carcinoma and its biological significance[J]. , 2013, 28(1): 67-71.

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