The research of myocardial damage in children with congenital heart diseases before and after paediatric cardiovascular intervention

Abstract

Abstract: Objective　To investigate the myocardial damage in congenital heart diseases after paediatric cardiovascular intervention by the madeinChina occluder through monitoring the changes of heart fatty acidbinding protein (H-FABP) and cardiac troponin I (cTnI) dynamically. Methods　A total of 24 patent ductus arteriosus (PDA) patients, 20 atrial septal defect (ASD) patients and 16 ventricular septal defect (VSD) patients were enrolled, and their serum levels of cTnI and H-FABP were monitored dynamically. Results　The results of serum H-FABP and cTnI concentrations were (1.28±0.57)μg/L and (0.02±0.01)μg /L at preoperative time, respectively. After the operation, they were (8.51±5.47)μg/L and (0.46±0.49)μg/L after (10±5) min， and (2.31±1.73)μg/L and (0.66±0.45)μg/L after 4 h， respectively, and then they were decreased obviously after 24 h with statistical significance (P<0.01). Conclusions　After paediatric cardiovascular intervention, it exists myocardial damage which is related to the kinds of congenital heart diseases. Compared with cTnI, the serum H-FABP is an early and sensitive marker for predicting myocardial damage.It is useful to prevent postoperative complications by monitoring H-FABP and cTnI.

Key words: Heart fatty acidbinding protein, Cardiac troponin I, Myocardial damage, Paediatric cardiovascular intervention

YAN Guochao;SHAO Yun;WU Yan;QI Guoqing. The research of myocardial damage in children with congenital heart diseases before and after paediatric cardiovascular intervention[J]. , 2012, 27(2): 135-137.

References

［1］Pees C， Haas NA， von der Beek J， et al. Cardiac troponin I is increased after interventional closure of atrial septal defects ［J］. Catheter Cardiovasc Interv, 2003， 58(1):124129.

［2］　秦玉明，王大为，杨世伟，等. 心肌钙蛋白在小儿先天性心脏病介入治疗中的变化［J］. 中华儿科杂志， 2005， 43 (12): 935936.

［3］　戴汝平.开拓介入治疗新领域——先天性心脏病的介入治疗.［J］. 中华心血管病杂志， 2000， 28(2): 85.

［4］　McCann CJ， Glover BM, Menown IB, et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T［J］. Eur Heart J, 2008, 29(23): 28432850.

［5］　Glatz JF， van der Vusse GJ， Simoons ML， et al. Fatty acidbinding protein and the early detection of acute myocardial infarction［J］. Clin Chim Acta， 1998， 272(1): 8792.

［6］　Liu H， Dong GH， Xu B， et al. Heart fatty acid binding protein in the rapid evaluation of myocardial damage following valve replacement surgery ［J］. Clin Chim Acta， 2005， 356 (12): 147153.

［7］　陈新春，朱敏敏，唐晓阳，等. cTnI、hFABP在不停跳冠状动脉旁路移植术68例围术期变化的研究［J］. 南京医科大学学报(自然科学版)， 2006， 26(4): 275278.

［8］　Baysal T， Oran B， Baspinar O, et al. Cardiac troponin I elevation in paediatric cardiac catheterization［J］. Anadolu Kardiyol Derg, 2005， 5(2):112115.

［9］　Pees C， Haas NA， von der Beek J, et al. Cardiac troponin I is increased after interventional closure of atrial septal defects［J］. Catheter Cardiovasc Interv, 2003, 58(1): 124129.

［10］　Baysal T， Oran B， Baspinar O, et al. Cardiac troponin I elevation in paediatric cardiac catheterization［J］. Anadolu Kardiyol Derg, 2005,5(2):112115.

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