Detection of human papillomavirus infection by channelization hybridization among Chinese women in central plains

Abstract

Abstract: Objective　To investigate the infection rate of human papillomavirus（HPV），the distribution of HPV subtypes and the relationship between HPV infection and age. Methods　Polymerase chain reaction（PCR） and channelization hybridization were used to detect the subtypes of HPV among 11 861 women. Results　The infection rate of HPV was 29.0%. The predominant subtype was high risk-HPV16（8.3%），followed by low risk-HPV6（6.0%），low risk-HPV11（5.5%），high risk-HPV52（4.6%） and high risk-HPV58（3.8%）. The infection rate of HPV was statistically significant in different age groups（P＜0.01）. The highest infection rate distributed in 20-30 years old group（42.8%），followed by 30- 40 years old group（25.7%），more than 50 years old group（23.2%） and 40-50 years old group（17.9%）. Conclusions　The predominant subtype of HPV infection is HPV16，and the 20-30 years old women have the highest infection rate in Chinese central plains.

Key words: Human papillomavirus, Genotyping, Channelization hybridization, Cervical cancer

XU Poshi，ZHAO Jing，CHEN Guanghui. Detection of human papillomavirus infection by channelization hybridization among Chinese women in central plains[J]. , 2012, 27(12): 1040-1042.

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