Research progress of lipid peroxidation in dysregulation of glucose and lipid metabolism

doi:10.3969/j.issn.1673-8640.2025.06.017

Abstract

Abstract:

Lipid peroxidation means the generation process of a series of peroxidation products from polyunsaturated fatty acids（PUFA） within cells under enzymatic or non-enzymatic processes. This process disrupts the structure and function of biological membranes，consequently leading to various diseases，particularly those associated with disrupted glucose and lipid metabolism such as type 2 diabetes mellitus，non-alcoholic fatty liver disease and cardiovascular diseases. The present study provides comprehensive summary of the 3 pathways of lipid peroxidation，elucidating the primary reactions occurring within each pathway and identifying key oxidative metabolites. Furthermore，it examines the connections between these lipid peroxidation pathways and disease development，with a specific focus on the effects of multiple oxidative metabolites on the progression of diseases. This review aims to offer theoretical guidance for future treatments of disorders related to lipid metabolism and the exploration of novel biomarkers.

Key words: Lipid peroxidation, Polyunsaturated fatty acid, Cyclooxygenase, Lipoxygenase, Cytochrome P450

CLC Number:

R446.1

CAO Shuxian, GAO Yinan, SONG Yufan, LU Sumei. Research progress of lipid peroxidation in dysregulation of glucose and lipid metabolism[J]. Laboratory Medicine, 2025, 40(6): 615-620.

Figures/Tables 4

References 47

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同工酶	氧化代谢产物	酶的分布	功能
COX	PGG₂、PGH₂、PGX₂、TXA₂	全身各处	血小板活化，抑癌或促癌，抑炎，水盐平衡或激素分泌
LOX	HPETE^①、HETE、EET、LX、LT	表皮、白细胞、肥大细胞、树突状细胞、淋巴细胞等	参与哮喘的形成，参与动脉粥样硬化的发生，促炎，抑炎，参与鱼鳞病的发生
CYP450	EET、HETE	全身各处	抑炎或促炎，参与高血压、糖尿病、肿瘤的发展

同工酶	氧化代谢产物	酶的分布	功能
COX	PGG₂、PGH₂、PGX₂、TXA₂	全身各处	血小板活化，抑癌或促癌，抑炎，水盐平衡或激素分泌
LOX	HPETE^①、HETE、EET、LX、LT	表皮、白细胞、肥大细胞、树突状细胞、淋巴细胞等	参与哮喘的形成，参与动脉粥样硬化的发生，促炎，抑炎，参与鱼鳞病的发生
CYP450	EET、HETE	全身各处	抑炎或促炎，参与高血压、糖尿病、肿瘤的发展

代谢产物	功能	参考文献
PGI₂	促炎，促进脂肪细胞分化	[27]
PGE₂	抑制前脂肪细胞分化，促进结肠癌发生、发展，抑制癌细胞凋亡，促进癌细胞增殖、侵袭和转移	[22]
PGD₂	参与哮喘形成，促炎	[24]
PGF2α	使血管收缩、血压升高，参与抑制脂肪生成	[20]
TX	诱导血小板活性、诱导血管生成	[26]

代谢产物	功能	参考文献
PGI₂	促炎，促进脂肪细胞分化	[27]
PGE₂	抑制前脂肪细胞分化，促进结肠癌发生、发展，抑制癌细胞凋亡，促进癌细胞增殖、侵袭和转移	[22]
PGD₂	参与哮喘形成，促炎	[24]
PGF2α	使血管收缩、血压升高，参与抑制脂肪生成	[20]
TX	诱导血小板活性、诱导血管生成	[26]

代谢产物	功能	参考文献
HETE	刺激平滑肌细胞收缩、迁移和增殖，激活内皮细胞功能障碍，促炎	[26]
TX	抑炎，抗纤维化	[34]