Laboratory Medicine ›› 2025, Vol. 40 ›› Issue (6): 621-624.DOI: 10.3969/j.issn.1673-8640.2025.06.018
Received:2024-07-25
Revised:2025-01-19
Online:2025-06-30
Published:2025-07-01
CLC Number:
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2025.06.018
| 病例 | 尿蛋白定量检测 | 尿mAlb/ TP比值/% | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TP/（mg·L-1） | mAlb/（mg·L-1） | β2-MG/（mg·L-1） | RBP/（mg·L-1） | α1-MG/（mg·L-1） | TF/（mg·L-1） | IgG/（mg·L-1） | α2-MG/（mg·L-1） | |||
| 病例1 | 553 | 7.0 | 0.52 | 0.17 | 15.9 | 1.46 | 3.77 | 0.1 | 1.27 | |
| 病例2 | 2 035 | 278.0 | 21.38 | 3.51 | 39.7 | 18.62 | 16.28 | 0.2 | 13.67 | |
| 病例3 | 2 667 | 71.7 | 64.96 | 34.94 | 86.6 | 6.68 | 3.00 | 0.6 | 2.69 | |
| 病例 | 尿蛋白电泳 | |||||||||
| 原始样本 | 经β-巯基乙醇处理后 | |||||||||
| 大分子蛋白/ % | 中分子蛋白/ % | 小分子蛋白/ % | λ轻链/（g·L-1） | 大分子蛋白/ % | 中分子蛋白/ % | 小分子蛋白/ % | λ轻链/（g·L-1） | |||
| 病例1 | 0.0 | 100.0 | 0.0 | 0.24 | 0.0 | 2.3 | 97.7 | 0.29 | ||
| 病例2 | 53.3 | 25.8 | 20.9 | 1.91 | 1.0 | 18.5 | 80.5 | 2.52 | ||
| 病例3 | 63.0 | 24.0 | 13.0 | 2.04 | 0.0 | 5.1 | 94.9 | 2.95 | ||
| 病例 | 尿蛋白定量检测 | 尿mAlb/ TP比值/% | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TP/（mg·L-1） | mAlb/（mg·L-1） | β2-MG/（mg·L-1） | RBP/（mg·L-1） | α1-MG/（mg·L-1） | TF/（mg·L-1） | IgG/（mg·L-1） | α2-MG/（mg·L-1） | |||
| 病例1 | 553 | 7.0 | 0.52 | 0.17 | 15.9 | 1.46 | 3.77 | 0.1 | 1.27 | |
| 病例2 | 2 035 | 278.0 | 21.38 | 3.51 | 39.7 | 18.62 | 16.28 | 0.2 | 13.67 | |
| 病例3 | 2 667 | 71.7 | 64.96 | 34.94 | 86.6 | 6.68 | 3.00 | 0.6 | 2.69 | |
| 病例 | 尿蛋白电泳 | |||||||||
| 原始样本 | 经β-巯基乙醇处理后 | |||||||||
| 大分子蛋白/ % | 中分子蛋白/ % | 小分子蛋白/ % | λ轻链/（g·L-1） | 大分子蛋白/ % | 中分子蛋白/ % | 小分子蛋白/ % | λ轻链/（g·L-1） | |||
| 病例1 | 0.0 | 100.0 | 0.0 | 0.24 | 0.0 | 2.3 | 97.7 | 0.29 | ||
| 病例2 | 53.3 | 25.8 | 20.9 | 1.91 | 1.0 | 18.5 | 80.5 | 2.52 | ||
| 病例3 | 63.0 | 24.0 | 13.0 | 2.04 | 0.0 | 5.1 | 94.9 | 2.95 | ||
| [1] | 沈立松, 路瑾. 现代蛋白电泳筛查和诊断的临床应用[M]. 上海: 上海科学技术出版社, 2019. |
| [2] | DE NOVELLIS D, FONTANA R, CAROBENE A, et al. Serum free light-chain ratio at diagnosis is associated with early renal damage in multiple myeloma:a case series real-world study[J]. Biomedicines, 2022, 10(7):1657. |
| [3] | 毛雪涵, 邓书会, 隋伟薇, 等. MGUS、原发性轻链型淀粉样变、MM及MM继发淀粉样变性患者的临床分析[J]. 中国实验血液学杂志, 2021, 29(3):812-818. |
| [4] | MILANI P, PALLADINI G, MERLINI G. Serum-free light-chain analysis in diagnosis and management of multiple myeloma and related conditions[J]. Scand J Clin Lab Invest Suppl, 2016, 245:S113-S118. |
| [5] |
ERDEM B K, DAVRAN F, YILMAZ V T, et al. The association of serum-free light-chain levels with markers of renal function[J]. Ren Fail, 2015, 37(6):1057-1060.
DOI PMID |
| [6] | CHEN C, CHEN P, FANG X. The FLC dimer with lambda type may false-migrate to the position of "albumin" band by urine protein electrophoresis on Sebia agarose gel-based detection system[J]. J Clin Lab Anal, 2019, 33(2):e22658. |
| [7] |
SÖLLING K. Polymeric forms of free light chains in serum from normal individuals and from patients with renal diseases[J]. Scand J Clin Lab Invest, 1976, 36(5):447-452.
PMID |
| [8] |
ABRAHAM R S, CHARLESWORTH M C, OWEN B A, et al. Trimolecular complexes of lambda light chain dimers in serum of a patient with multiple myeloma[J]. Clin Chem, 2002, 48(10):1805-1811.
PMID |
| [9] | KAPLAN B, LIVNEH A, SELA B A. Immunoglobulin free light chain dimers in human diseases[J]. ScientificWorldJournal, 2011, 11:726-735. |
| [10] | PERKINS M, THEILER R, LUNTE S, et al. Determination of the origin of charge heterogeneity in a murine monoclonal antibody[J]. Pharm Res, 2000, 17(9):1110-1117. |
| [11] |
LYUBARSKAYA Y, HOUDE D, WOODARD J, et al. Analysis of recombinant monoclonal antibody isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity[J]. Anal Biochem, 2006, 348(1):24-39.
PMID |
| [12] | KAPLAN B, RAMIREZ-ALVARADO M, SIKKINK L, et al. Free light chains in plasma of patients with light chain amyloidosis and non-amyloid light chain deposition disease. High proportion and heterogeneity of disulfide-linked monoclonal free light chains as pathogenic features of amyloid disease[J]. Br J Haematol, 2009, 144(5):705-715. |
| [13] | 王淑惠, 孙冰梅, 高静, 等. 非浓缩尿蛋白电泳诊断2型糖尿病肾病的应用价值[J]. 医疗装备, 2017, 30(10):7-8. |
| [14] | 陈鹏. SDS-AGE尿蛋白电泳检测在糖尿病肾病中的临床价值[J]. 实验与检验医学, 2010, 28(3):253-254. |
| [1] | . [J]. Laboratory Medicine, 2025, 40(6): 601-605. |
| [2] | MA Jingyun, WANG Mengmeng, XIONG Boyu, DAI Zhuowen, PAN Yueyue, WANG Qiong. Research progress in phenotypic characteristics and treatment efficacy evaluation of acute promyelocytic leukemia variants [J]. Laboratory Medicine, 2025, 40(6): 606-614. |
| [3] | CAO Shuxian, GAO Yinan, SONG Yufan, LU Sumei. Research progress of lipid peroxidation in dysregulation of glucose and lipid metabolism [J]. Laboratory Medicine, 2025, 40(6): 615-620. |
| [4] | GUO Jingjing, LI Haixia, MA Qian, HUANG Haiming, ZENG Ziyi, AN Chongwen, PANG Lu. A retrospective analysis of serum 25（OH）D levels and related factors in a physical examination population in a Grade 3 Class A hospital in Beijing [J]. Laboratory Medicine, 2025, 40(6): 545-550. |
| [5] | YANG Qi, LIN Ying, GUO Nan, LI Xiaobin, SHANG E, LI Hongmin, YAO Xingwei. Changes of coagulation function in elderly patients with severe pneumonia infected by different Gram-negative bacteria [J]. Laboratory Medicine, 2025, 40(6): 560-564. |
| [6] | . [J]. Laboratory Medicine, 2025, 40(6): 596-600. |
| [7] | GONG Xiaolin, DENG Kun, WU Jun, REN Chuanli, XU Songxiao, LI Shengjie, LI Bo, YANG Dagan, SHEN Han, ZHANG Yi, CHEN Ming, WU Yongkang, LUO Huaichao, YUAN Xu, XU Huaguo, GONG Qian, LI Xin, GUAN Ming. AI technology reshaping laboratory medicine from automation to intelligent decision-making [J]. Laboratory Medicine, 2025, 40(5): 413-420. |
| [8] | WU Yazhou, LI Hanhua, MENG Leijun, CHEN Xuefei, SUN Yuhan, WENG Wenhao, ZHENG Bing. Fusobacterium nucleatum promoting chemoresistance of colorectal cancer cells via lncRNA XIST [J]. Laboratory Medicine, 2025, 40(5): 428-436. |
| [9] | CHEN Qun, LUO Qizhi, LIANG Hongmei, WU Yuanru, HE Dahui, LIAO Guoqiang, LIN Liyun, LU Xiaojing, YANG Dandan. Change and role of glycolipid metabolism markers in patients with benign prostatic hyperplasia [J]. Laboratory Medicine, 2025, 40(5): 443-449. |
| [10] | LI Yazhou, SU Min, ZHANG Jinghao, FANG Yi, WANG Su, WANG Shiwen, ZHAO Hu. Roles of single and combined determinations of CRP，HBP，CLR and HAR in the diagnosis of bloodstream infection in elderly patients [J]. Laboratory Medicine, 2025, 40(5): 489-492. |
| [11] | XU Dandan. Role of lactic acid/albumin ratio in short-term and long-term prognosis evaluation of ventilation therapy in AECOPD patients [J]. Laboratory Medicine, 2025, 40(5): 493-498. |
| [12] | YAO Lifeng, ZHANG Ling. Research progress on clinical significance of monocyte distribution width in infection and inflammatory diseases [J]. Laboratory Medicine, 2025, 40(5): 503-507. |
| [13] | ZHENG Yong, LÜ Lei, HE Kai. Clinical roles of serum GDF15 and YKL-40 in elderly patients with gallbladder cancer [J]. Laboratory Medicine, 2025, 40(4): 377-382. |
| [14] | GUI Jing, WANG Feng, CAI Yumao, HONG Chuangyue, YANG Hui. Correlation between oxidized high-density lipoprotein and comorbidity of T2DM and PTB [J]. Laboratory Medicine, 2025, 40(4): 350-357. |
| [15] | CHEN Weilong, WANG Yongbing, CHEN Zegang. Correlation between ZBED3，CYFRA21-1，VEGF and short-term mortality risk in patients with advanced liver cancer [J]. Laboratory Medicine, 2025, 40(4): 338-343. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
