Abstract:

Objective To investigate the prognostic role of intestinal fatty acid binding protein（IFABP） in critically ill patients. Methods A total of 123 critically ill patients were enrolled,and the clinical data,including age,sex,basic diseases and quick sequential organ failure assessment（qSOFA） score,were recorded within 24 h of admission. According to the outcome of 28 d,they were classified into survival group（95 cases） and death group（28 cases）. Totally,35 healthy subjects were enrolled as control group. IFABP and C-reactive protein（CRP） levels were determined. The efficacy of each index was evaluated by receiver operating characteristic（ROC） curve,and the risk factors of death in critically ill patients were screened by multivariate Logistic regression analysis of binary variables. Results The levels of serum IFABP and CRP in death group,survival group and control group decreased gradually（P<0.05）. ROC curve analysis showed that the areas under curves（AUC）of IFABP,CRP and qSOFA score in the mortality risk of critically ill patients were 0.865,0.750 and 0.808,respectively. Logistic regression analysis showed that IFABP≥36.20 ng/mL,CRP≥36.82 mg/L and qSOFA score≥2.0 were risk factors for death in critically ill patients [odds ratios（OR） were 10.668,3.775 and 9.048,95% confidence intervals（CI） were 3.498-32.533,1.156-12.325 and 1.818-45.038,respectively]. Conclusions IFABP may be an effective predictor of mortality risk in critically ill patients,and its increase may indicate the risk of death in critically ill patients.

Key words: Intestinal fatty acid binding protein, Critical illness, Prognosis