Laboratory Medicine ›› 2021, Vol. 36 ›› Issue (12): 1229-1233.DOI: 10.3969/j.issn.1673-8640.2021.012.007
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FAN Minghe, LIN Guangmin(), HUANG Ruijie
Received:
2020-09-03
Online:
2021-12-30
Published:
2021-12-29
Contact:
LIN Guangmin
CLC Number:
FAN Minghe, LIN Guangmin, HUANG Ruijie. TLR4 mRNA and HO-1 level in evaluating the condition and prognosis of ICVD[J]. Laboratory Medicine, 2021, 36(12): 1229-1233.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2021.012.007
引物名称 | 序列(5'~3') | 引物大小/bp |
---|---|---|
TLR4 | 上游 TGGATACGTTTCTTATAA | 111 |
下游 GAAATGGAGGCACCCCTT | ||
β-actin | 上游 GAGCCTCGCCTTTGCCGATCC | 139 |
下游 CGATGCCGTCTCGATGGGG |
引物名称 | 序列(5'~3') | 引物大小/bp |
---|---|---|
TLR4 | 上游 TGGATACGTTTCTTATAA | 111 |
下游 GAAATGGAGGCACCCCTT | ||
β-actin | 上游 GAGCCTCGCCTTTGCCGATCC | 139 |
下游 CGATGCCGTCTCGATGGGG |
组别 | 例数 | 吸烟史 | 饮酒史 | 高血压史 | 糖尿病史 | 心脏疾病史 | 高脂血症 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | |||||||
ICVD组 | 324 | 163 | 161 | 138 | 185 | 82 | 242 | 79 | 245 | 95 | 229 | 73 | 251 | |||||
正常对照组 | 324 | 68 | 256 | 70 | 254 | 34 | 290 | 31 | 293 | 38 | 286 | 24 | 300 | |||||
χ2值 | 63.605 | 34.446 | 26.602 | 27.907 | 33.336 | 32.718 | ||||||||||||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
组别 | 例数 | 吸烟史 | 饮酒史 | 高血压史 | 糖尿病史 | 心脏疾病史 | 高脂血症 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | 有 | 无 | |||||||
ICVD组 | 324 | 163 | 161 | 138 | 185 | 82 | 242 | 79 | 245 | 95 | 229 | 73 | 251 | |||||
正常对照组 | 324 | 68 | 256 | 70 | 254 | 34 | 290 | 31 | 293 | 38 | 286 | 24 | 300 | |||||
χ2值 | 63.605 | 34.446 | 26.602 | 27.907 | 33.336 | 32.718 | ||||||||||||
P值 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
ICVD组 | 324 | 4.18±2.52 | 1.21±0.57 |
正常对照组 | 324 | 2.10±1.11 | 0.31±0.10 |
t值 | 10.369 | 27.994 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
ICVD组 | 324 | 4.18±2.52 | 1.21±0.57 |
正常对照组 | 324 | 2.10±1.11 | 0.31±0.10 |
t值 | 10.369 | 27.994 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
轻度狭窄组 | 93 | 3.06±1.80 | 0.87±0.41 |
中度狭窄组 | 152 | 4.11±2.32* | 1.11±0.50* |
重度狭窄组 | 79 | 5.89±2.19*# | 1.36±0.44*# |
F值 | 56.836 | 22.012 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
轻度狭窄组 | 93 | 3.06±1.80 | 0.87±0.41 |
中度狭窄组 | 152 | 4.11±2.32* | 1.11±0.50* |
重度狭窄组 | 79 | 5.89±2.19*# | 1.36±0.44*# |
F值 | 56.836 | 22.012 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
轻度损伤组 | 88 | 3.02±1.90 | 0.80±0.39 |
中度损伤组 | 153 | 4.48±2.30* | 1.18±0.58* |
重度损伤组 | 83 | 5.88±2.32*# | 1.56±0.30*# |
F值 | 31.098 | 39.024 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
轻度损伤组 | 88 | 3.02±1.90 | 0.80±0.39 |
中度损伤组 | 153 | 4.48±2.30* | 1.18±0.58* |
重度损伤组 | 83 | 5.88±2.32*# | 1.56±0.30*# |
F值 | 31.098 | 39.024 | |
P值 | 0.000 | 0.000 |
项目 | HO-1 | TLR4 mRNA |
---|---|---|
狭窄程度 | ||
rs值 | 0.770 | 0.859 |
P值 | <0.001 | <0.001 |
NIHSS评分 | ||
r值 | 0.792 | 0.845 |
P值 | <0.001 | <0.001 |
项目 | HO-1 | TLR4 mRNA |
---|---|---|
狭窄程度 | ||
rs值 | 0.770 | 0.859 |
P值 | <0.001 | <0.001 |
NIHSS评分 | ||
r值 | 0.792 | 0.845 |
P值 | <0.001 | <0.001 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
预后较好组 | 229 | 3.44±1.30 | 0.84±0.43 |
预后不良组 | 95 | 6.30±2.21 | 1.76±0.64 |
t值 | 11.726 | 10.909 | |
P值 | 0.000 | 0.000 |
组别 | 例数 | HO-1/(ng/mL) | TLR4 mRNA |
---|---|---|---|
预后较好组 | 229 | 3.44±1.30 | 0.84±0.43 |
预后不良组 | 95 | 6.30±2.21 | 1.76±0.64 |
t值 | 11.726 | 10.909 | |
P值 | 0.000 | 0.000 |
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