Correlations of NLR and PLR with hyperlipidemia

doi:10.3969/j.issn.1673-8640.2020.08.006

Abstract

Abstract:

Objective To investigate the correlations of neutrophil-to-lymphocyte ratio（NLR） and platelet-to-lymphocyte ratio（PLR） with hyperlipidemia（HLP）. Methods The study included 495 patients with HLP,and their results of laboratory parameters were analyzed retrospectively. Totally,500 healthy subjects were enrolled as control group. Results HLP group had higher NLR and PLR compared to those of control group（P=0.007）. In the univariate analysis,white blood cell,hemoglobin,NLR and PLR were moderately correlated with HLP. Receiver operating characteristic（ROC） curve analysis showed that the optimal cut-off value for NLR was 1.71（P<0.001）. The sensitivity was 68.0%,and the specificity was 78.5%. The predictive strength of NLR was better than those of the other parameters. A strong positive correlation was revealed between the severity of HLP and NLR. Conclusions Patients with HLP have higher NLR and PLR compared to healthy subjects. NLR increases with the severity of HLP.

Key words: Hyperlipidemia, Cardiovascular and cerebrovascular disease, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio

CLC Number:

R446.1

ZHANG Tao, LIU Qin, LIU Aiping, DING Yaodong. Correlations of NLR and PLR with hyperlipidemia[J]. Laboratory Medicine, 2020, 35(8): 767-770.

Figures/Tables 5

References 12

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项目	回归系数	95%CI	OR值	P值
ALT	-0.033	0.955~0.976	0.958	<0.001
AST	-0.049	0.931~974	0.952	<0.001
TB	-0.058	1.020~1.100	1.059	0.19
Alb	-0.080	0.878~0.972	0.996	0.011
Glu	0.356	0.509~0.963	0.701	0.029
HbA_1c	-0.874	0.260~0.669	0.417	0.003
FT₄	-0.100	0.849~0.964	0.905	<0.001
FT₃	-0.269	0.589~0.992	0.764	0.043
Hb	-0.032	0.958~0.980	0.969	<0.001
RDW	-0.004	1.007~1.100	1.052	0.025
WBC计数	0.010	0.874~1.302	1.010	0.044
NEUT#	-0.154	0.746~0.985	0.857	0.029
PLT计数	-0.004	0.993~0.998	0.996	<0.001
NLR	0.32	1.103~1.758	1.405	0.016
PLR	0.105	1.022~1.657	1.291	0.023

项目	回归系数	95%CI	OR值	P值
ALT	-0.033	0.955~0.976	0.958	<0.001
AST	-0.049	0.931~974	0.952	<0.001
TB	-0.058	1.020~1.100	1.059	0.19
Alb	-0.080	0.878~0.972	0.996	0.011
Glu	0.356	0.509~0.963	0.701	0.029
HbA_1c	-0.874	0.260~0.669	0.417	0.003
FT₄	-0.100	0.849~0.964	0.905	<0.001
FT₃	-0.269	0.589~0.992	0.764	0.043
Hb	-0.032	0.958~0.980	0.969	<0.001
RDW	-0.004	1.007~1.100	1.052	0.025
WBC计数	0.010	0.874~1.302	1.010	0.044
NEUT#	-0.154	0.746~0.985	0.857	0.029
PLT计数	-0.004	0.993~0.998	0.996	<0.001
NLR	0.32	1.103~1.758	1.405	0.016
PLR	0.105	1.022~1.657	1.291	0.023

项目	AUC	95%CI	最佳临界值	敏感性	特异性	P 值
WBC计数	0.551	0.515~0.587	6.03	0.564	0.606	0.005
Hb	0.538	0.502~0.574	154.50	0.533	0.654	0.038
NLR	0.652	0.596~0.681	1.71	0.680	0.785	<0.001
PLR	0.628	0.583~0.663	106.43	0.618	0.640	<0.001

项目	AUC	95%CI	最佳临界值	敏感性	特异性	P 值
WBC计数	0.551	0.515~0.587	6.03	0.564	0.606	0.005
Hb	0.538	0.502~0.574	154.50	0.533	0.654	0.038
NLR	0.652	0.596~0.681	1.71	0.680	0.785	<0.001
PLR	0.628	0.583~0.663	106.43	0.618	0.640	<0.001