Morphological and clinical characteristics of near-tetraploid acute lymphocytic leukemia

doi:10.3969/j.issn.1673-8640.2020.07.004

Abstract

Abstract:

Objective To study the morphological and clinical characteristics of near-tetraploid acute lymphocytic leukemia（NT-ALL）. Methods All the clinical data and laboratory examinations（blood smear,bone marrow morphology,immunophenotype and genetic examinations）of 1 NT-ALL patient were collected for comprehensive analysis. Results The patient had acute abdomen. According to bone marrow morphology and immunophenotype,he was diagnosed as B-acute lymphocytic leukemia（B-ALL）,and the chromosome was near-tetraploid karyotype（81-103 chromosome）. Conclusions Adult NT-ALL is rare. The morphological characteristics are different from those of classic acute lymphocytic leukemia（ALL）. The nuclear shape is irregular,the nucleolus is large,the vacuole is large,and the prognosis is poor,which may be related to the abnormal karyotype of near-tetraploid.

Key words: Chromosome, Near-tetraploid karyotype, Acute lymphocytic leukemia, Morphological characteristic, Prognosis

CLC Number:

R446.1

ZHANG Xiaohui, TAO Chaoxin, BAI Mingming, CHEN Lei, ZHANG Yuna, DU Huijuan, XING Jiangtao, ZHU Yun. Morphological and clinical characteristics of near-tetraploid acute lymphocytic leukemia[J]. Laboratory Medicine, 2020, 35(7): 645-650.

Figures/Tables 5

References 14

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