Influence of common drugs on clinical test results

doi:10.3969/j.issn.1673-8640.2019.11.017

Abstract

Abstract:

This review focuses on the influence mechanism of common drugs on clinical test results,including the in vivo effect of drugs and metabolites,for example,pharmacological effects,bio-affinity effects,drug metabolism and the influence of metabolites. The influence of common drugs,including antibiotics,cardiovascular drugs,antipyretic analgesics,vitamins,hormone drugs,anti-cancer drugs,diabetes drugs,antithyroid drugs,psychotropic drugs,on clinical test results were introduced. This review finally summarizes the ways on reducing the effect of drugs on clinical test results,including timely and effective communication with clinicians and continuous improvement of clinical test methods.

Key words: Common drugs, Clinical test results, Influence mechanism

CLC Number:

R446.1

ZHU Yuqing, ZHAO Xiaojun, CHEN Ziqi, WANG Hualiang. Influence of common drugs on clinical test results[J]. Laboratory Medicine, 2019, 34(11): 1038-1044.

References 19

[1]	尚红,王毓三,申子瑜. 全国临床检验操作规程[M]. 4版. 北京:人民卫生出版社,2014:1005.
[2]	赵勇. 浅谈药物对临床医学检验结果的影响[J]. 中国医药指南,2015,13(28):286-287.
[3]	SIEST G,DAWKINS S J,GALTEAU M M.Drug effects on clinical laboratory tests[J]. J Pharm Biomed Anal,1983,1(3):247-257.
[4]	GARRATTY G,ARNDT P A.Positive direct antiglobulin tests and haemolytic anemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells[J]. Br J Haematol,1998,100(4):777-783.
[5]	MORELL-GARCIA D,BAUGA J M,BARCELÓ A,et a1. Usefulness of Benedict's test for the screening of galactosemia[J]. Clin Biochem,2014,47(9):857-859.
[6]	MACCARA M E,ANGARAN D M.Cephalosporin-clinitest interaction:comparison of cephalothin,cefazolin and cephradine[J]. Am J Hosp Pharm,1978,35(9):1064-1067.
[7]	魏晔,袁晓华,李海波. 美国头孢菌素类抗生素说明书中关于药物干扰检验内容的分析[J]. 中国抗生素杂志,2017,42(5):340-342.
[8]	陈秋艳. 肾上腺素和利福平对临床生化检验的影响[J]. 海峡药学,2013,25(6):261-262.
[9]	朱莹,凌敏,陈丽华,等. 拟肾上腺类药品说明书中有关药物干扰检验的内容分析[J]. 检验医学与临床,2016,13(19):2781-2782.
[10]	李学梅. 常见药物对临床检验结果的影响分析[J]. 中国药业,2014,23(16):88-89.
[11]	COMBS G F.The vitamins:fundamental aspects in nutrition and health[M]. San Diego:Elsevier,1998:331-344.
[12]	PEYRO SAINT PAUL L,DEBRUYNE D,BERNARD D,et al. Pharmacokinetics and pharmacodynamics of MD1003(high-dose biotin) in the treatment of progressive multiple sclerosis[J]. Expert Opin Drug Metab Toxicol,2016,12(3):327-344.
[13]	ROSS D S,BURCH H B,COOPER D S,et al.2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis[J]. Thyroid,2016,26(10):1343-1421.
[14]	WIJERATNE N G,DOERY J C,LU Z X.Positive and negative interference in immunoassays following biotin ingestion:a pharmacokinetic study[J]. Pathology,2012,44(7):674-675.
[15]	KUMMER S,HERMSEN D,DISTELMAIER F.Biotin treatment mimicking Graves' disease[J]. N Engl J Med,2016,375(7):704-706.
[16]	ALI M,RAJAPAKSHE D,CAO L,et al.Discordant analytical results caused by biotin interference on diagnostic immunoassays in a pediatric hospital[J]. Ann Clin Lab Sci,2017,47(5):638-640.
[17]	TRAMBAS C,LU Z,YEN T,et al.Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays[J]. Ann Clin Biochem,2018,55(2):205-215.
[18]	柴淼,罗晓慧,潘宇,等.浅析药物对临床医学检验结果的影响[J]. 中外医疗,2011,30(10):188.
[19]	毛建红. 药物对临床检验结果的分析[J]. 中外医学研究,2012,10(35):153.