Influence of active human cytomegalovirus infection on uremia

doi:10.3969/j.issn.1673-8640.2019.04.004

Abstract

Abstract:

Objective To investigate the influence of active human cytomegalovirus（HCMV） infection on uremia. Methods The peripheral blood samples of 13 uremia patients with active HCMV infection,58 uremia patients with latent HCMV infection and 58 healthy subjects（healthy control group） were collected. The parameters,HCMV IgG antibody,HCMV IgM antibody,HCMV IE-1,HCMV pp65 antigen,serum creatinine（Cr）,blood urea nitrogen（BUN）,red blood cell（RBC） count,hematocrit（HCT）,hemoglobin（Hb） and lymphocyte percentage were determined. The influence of active HCMV infection on uremia was evaluated. Results Cr,BUN,RBC count,HCT and Hb in uremia groups had statistical significance compared with those in healthy control group（P<0.05）. In active HCMV infection group,Cr,BUN and lymphocyte percentage were increased compared with latent HCMV infection group（P<0.05,P<0.01）,and RBC count,HCT and Hb were decreased without statistical significance（P>0.05）. Conclusions Active HCMV infection might be involved in the pathogenesis of uremia.

Key words: Human cytomegalovirus, Infection, Uremia

CLC Number:

R446.1

XIA Jianping, HUANG Jianfeng, ZHANG Zihong, GONG Fang, QIAN Chunyan. Influence of active human cytomegalovirus infection on uremia[J]. Laboratory Medicine, 2019, 34(4): 309-312.

Figures/Tables 3

References 9

[1]	周玉洁,张亚,徐秀兰,等. 无偿献血人群人疱疹病毒8型和巨细胞病毒及细小病毒B19感染流行情况调查[J]. 中华医院感染学杂志,2017,27(3):514-517.
[2]	GRIFFITHS P,LUMLEY S.Cytomegalovirus[J]. Curr Opin Infect Dis,2014,27(6):554-559.
[3]	王建,曹伟锋,毛月燕,等. 流式细胞术检测人巨细胞病毒活动性感染检测方法的建立及检测效果评价[J]. 病毒学报,2017,33(3):450-454.
[4]	FORNARA O,BARTEK J Jr,RAHBAR A,et al.Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impact[J]. Cell Death Differ,2016,23(2):261-269.
[5]	王海燕. 肾脏病学[M]. 3版. 北京:人民卫生出版社,2008:1897.
[6]	王玉瑛,汤淑斌,焦爱萍,等. 巨细胞病毒感染相关肾损伤的临床分析[J]. 中国妇幼健康研究,2016,27(4):476-479.
[7]	高慧慧,陶然,俞惠民,等. 人巨细胞病毒潜伏感染机制的研究进展[J]. 病毒学报,2016,32(1):82-87.
[8]	PARRY H M,ZUO J,FRUMENTO G,et al.Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years[J]. Immun Ageing,2016,13:1.
[9]	陈华友. 巨细胞病毒感染患儿血巨细胞病毒载量与细胞免疫水平的关系[J]. 中国妇幼保健,2016,31(20): 4192-4194.

组别	例数	HCMV IgG抗体（AU/mL）	HCMV IgM抗体		HCMV IE-1基因		HCMV pp65抗原
组别	例数	HCMV IgG抗体（AU/mL）	例数	百分比（%）	例数	百分比（%）	例数	百分比（%）
健康对照组	58	355.72±238.44	0	0.00	1	1.72	0	0.00
尿毒症组
HCMV潜伏感染组	58	359.35±249.31	1	1.72	0	0.00	0	0.00
HCMV活动感染组	13	371.95±225.25	4	30.77^*#	11	84.62^*#	10	76.92^*#

组别	例数	HCMV IgG抗体（AU/mL）	HCMV IgM抗体		HCMV IE-1基因		HCMV pp65抗原
组别	例数	HCMV IgG抗体（AU/mL）	例数	百分比（%）	例数	百分比（%）	例数	百分比（%）
健康对照组	58	355.72±238.44	0	0.00	1	1.72	0	0.00
尿毒症组
HCMV潜伏感染组	58	359.35±249.31	1	1.72	0	0.00	0	0.00
HCMV活动感染组	13	371.95±225.25	4	30.77^*#	11	84.62^*#	10	76.92^*#

组别	例数	Cr （μmol/L）	BUN （mmol/L）	RBC计数（×10¹²g/L）	HCT （%）	Hb （g/L）	淋巴细胞百分比（%）
健康对照组	58	65.97±14.46	4.62±1.35	5.08±1.37	43.90±3.93	144.34±13.73	34.32±8.04
尿毒症组
HCMV潜伏感染组	58	173.53±45.64^*	11.45±1.83^*	3.99±1.20^*	35.89±4.39^*	116.34±10.62^*	25.72±11.47^*
HCMV活动感染组	13	191.51±56.01^*#	12.70±3.88^*#	3.82±1.04^*	33.95±5.86^*	111.17±17.85^*	32.78±5.53^##

组别	例数	Cr （μmol/L）	BUN （mmol/L）	RBC计数（×10¹²g/L）	HCT （%）	Hb （g/L）	淋巴细胞百分比（%）
健康对照组	58	65.97±14.46	4.62±1.35	5.08±1.37	43.90±3.93	144.34±13.73	34.32±8.04
尿毒症组
HCMV潜伏感染组	58	173.53±45.64^*	11.45±1.83^*	3.99±1.20^*	35.89±4.39^*	116.34±10.62^*	25.72±11.47^*
HCMV活动感染组	13	191.51±56.01^*#	12.70±3.88^*#	3.82±1.04^*	33.95±5.86^*	111.17±17.85^*	32.78±5.53^##

[1]	WANG Huiying, TANG Yu, DONG Lili, WANG Jing. Role of Mycoplasma pneumoniae RNA determination in diagnosis and efficacy monitoring of pneumonia in children [J]. Laboratory Medicine, 2023, 38(9): 865-869.
[2]	ZHAO Jing, LI Yongqin, LI Yan, FAN Weiguang, YANG Xuegang. Roles of IP-10，SAA，hs-CRP，PCT and CD4⁺ T cell count determinations in HIV/AIDS patients with opportunistic infection [J]. Laboratory Medicine, 2023, 38(8): 725-729.
[3]	ZHANG Na, NIU Weihua, SUN Yuanyuan, JIA Mei. CMV and EBV co-infection affecting patient prognosis after hematopoietic stem cell transplantation [J]. Laboratory Medicine, 2023, 38(8): 760-765.
[4]	WANG Chao, ZHAO Yu. Research progress on formation mechanism and eradication strategy of bacterial persisters [J]. Laboratory Medicine, 2023, 38(8): 790-795.
[5]	REN Yanfei, ZHANG Min, YANG Tao, LI Rongkai, LIANG Xin. Analysis of pathogenic epidemiology of patients with lower respiratory tract infection in respiratory intensive care unit [J]. Laboratory Medicine, 2023, 38(2): 157-162.
[6]	WANG Dongjiang, GUO Jian. Advance in laboratory diagnosis of invasive fungal infection [J]. Laboratory Medicine, 2023, 38(2): 179-185.
[7]	GU Yi, WANG Rui, DENG Jie, YANG Yijing, ZHOU Wangke, CHEN Yunuo, CHEN Xiaosong, SHEN Wei, ZHOU Jingyi. Differential analysis and prognostic diagnostic value of inflammatory biomarkers in liver transplantation in patients with severe hepatitis and cirrhosis [J]. Laboratory Medicine, 2023, 38(11): 1044-1051.
[8]	LU Qiyuan, LU Jianhua. Biomarker research progress for the diagnosis of periprosthetic joint infection [J]. Laboratory Medicine, 2023, 38(10): 997-1002.
[9]	LI Daming, LÜ Xing, JIANG Chuanhao, HU Min. Clinical application of gene chip technology for determining respiratory pathogens rapialy in pulmonary infection patients after renal transplantation [J]. Laboratory Medicine, 2022, 37(9): 864-867.
[10]	PAN Fen, PAN Yuxuan, SHI Yingying, YU Fangyuan, ZHANG Hong. UroQuick rapid urine culture technique for urinary tract infection in children [J]. Laboratory Medicine, 2022, 37(7): 652-656.
[11]	CHEN Hanlu, WU Shenghai. Influence factors of blood culture negative results and progress of pathogen detection in bloodstream infection [J]. Laboratory Medicine, 2022, 37(7): 688-694.
[12]	TANG Jin, PAN Yunqi, YANG Yumei, WU Qiong, WANG Jianqiang, LI Yungai, DI Jianzhong. Research progress of methicillin-resistant Staphylococcus aureus screening and decolonization to reduce surgical site infection [J]. Laboratory Medicine, 2022, 37(5): 489-492.
[13]	WANG Jianying, WANG Shanshan, ZHU Jun, HUANG Xiaochun, WAN Yuxiang, LIU Yun. Distribution and drug resistance of respiratory infection pathogens in patients with lung cancer after chemotherapy [J]. Laboratory Medicine, 2022, 37(4): 356-359.
[14]	SHANG Xipeng, LI Sha, DU Jinghui, LIU Xu. Research status of Actinotignum schaalii [J]. Laboratory Medicine, 2022, 37(4): 392-395.
[15]	XIE Yongping, HUA Chunzhen, WEI Linlin, WANG Hongjiao, WANG Gaoliang, LI Jianping. Evaluation of nasopharyngeal swab bacterial culture in pathogenic diagnosis in children with bacterial respiratory tract infection [J]. Laboratory Medicine, 2022, 37(3): 201-204.