Abstract:

Objective To investigate the roles of serum galactomannan （GM） antigen and Aspergillus fumigatus antibodies in the diagnosis of invasive pulmonary aspergillosis （IPA）. Methods A total of 124 patients with suspected IPA were enrolled and classified into IPA group （46 cases） and non-IPA group （78 cases）. Serum GM antigen and Aspergillus fumigatus IgG and IgM antibodies were determined,and the clinical data were analyzed retrospectively. Results There were 18 cases confirmed by pathological examinations and 28 cases confirmed by clinical diagnosis in IPA group. When the cut-off values of GM were 0.5 and 1.0 ng/mL,the sensitivities were 58.7% and 50.0%,and the specificities were 74.4% and 83.3%,respectively. The sensitivity and specificity of Aspergillus fumigatus IgG antibody were 80.4% and 91.0%,and those of Aspergillus fumigatus IgM antibody were 71.7% and 87.2%. The levels of IgG and IgM in IPA group were higher than those in non-IPA group （P<0.05）. Conclusions Serological tests have high specificities （>80%） in the diagnosis of IPA,especially GM antigen （the cut-off value of GM is 1.0 ng/mL）and Aspergillus fumigatus IgG and IgM antibodies. The sensitivity and specificity of Aspergillus fumigatus IgG antibody are better than those of Aspergillus fumigatus IgM antibody．

Key words: Galactomannan antigen, Aspergillus fumigatus antibody, Invasive pulmonary aspergillosis