Abstract:

Objective To provide scientific data for supporting clinical practice by analyzing the internal imprecision status of clinical routine chemical determination items in laboratories.Methods The data of median level from the Internal Quality Control Program from 159 hospitals were collected and evaluated,and the total coefficients of variation for 21 clinical routine chemical determination items [albumin（Alb）,alkaline phosphatase（ALP）,alanine aminotransferase（ALT）,amylase（Amy）,aspartate aminotransferase（AST）,total calcium（Ca）,creatine kinase（CK）,chlorine（Cl）,creatinine（Cr）,gamma glutamyltransferase（GGT）,glucose（Glu）,potassium（K）,lactate dehydrogenase（LDH）,sodium（Na）,inorganic phosphate（P）,total bilirubin（TB）,total cholesterol（TC）,triglyceride（TG）,total protein（TP）,uric acid（UA） and urea] were analyzed. The consistency of 21 clinical routine chemical determination items was analyzed according to WS/T 403—2012 as standard.Results Except Cl and Ca,the imprecisions（medians） of other determination items were lower than the WS/T 403—2012 standard. The overall consistency rates of Cl,Ca,TP and urea were <60%. Grouped statistics for medical institutions showed more extreme data,among which the consistency rate of Ca had statistical significance between the tertiary and the secondary medical institutions（χ²=5.12,P<0.05）. There was no statistical significance for the consistency rates of the other determination items（P>0.05）.Conclusions The imprecision status of routine chemical determination items in Anhui meets clinical basic demand,and some determination items need to be improved.

Key words: Imprecision, Clinical chemistry, Routine determination item