Elevation of interleukin-37b-producing lymphocyte proportion in patients with active pulmonary tuberculosis

doi:10.3969/j.issn.1673-8640.2017.05.011

Abstract

Abstract:

Objective To investigate the proportion of interleukin （IL）-37b-producing lymphocytes in patients with active pulmonary tuberculosis （ATB）. Methodse IL-37b-producing lymphocytes in peripheral blood from 42 patients with ATB were determined by flow cytometry,and the 8 patients were followed up. A total of 10 healthy subjects were enrolled as healthy control group. Results The proportion of IL-37b-producing lymphocytes in patients with ATB was higher than that in healthy control group,and it was decreased after treatment in the 8 followed-up patients. The proportion of IL-37b-producing lymphocytes in patients with positive tuberculosis antibody and positive sputum smear were higher than those in patients with negative tuberculosis antibody and negative sputum smear,respectively. The proportion of IL-37b-producing lymphocytes in patients received treatment again was higher than that in patients received initial treatment. The proportion of IL-37b-producing lymphocytes in peripheral blood mononuclear cell （PBMC）increased after the stimulation by bacillus Calmette-Guerin vaccination,especially for ATB patients. Conclusions The proportion of IL-37b-producing lymphocytes in patients with ATB is correlated with the severity and prognosis of ATB. The proportion of IL-37b-producing lymphocytes might be a parameter for evaluating the curative effect in ATB.

Key words: Interleukin-37b, Lymphocytes, Flow cytometry, Active pulmonary tuberculosis

CLC Number:

R446.62

LIU Ganbin, ZHANG Junai, DAI Youchao, ZHUANG Zegang, CHEN Chen, YI Lailong, XU Junfa. Elevation of interleukin-37b-producing lymphocyte proportion in patients with active pulmonary tuberculosis[J]. Laboratory Medicine, 2017, 32(5): 394-398.

Figures/Tables 3

References 16

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