Abstract:

Objective Mantle cell lymphoma（MCL） is a rare class of non-Hodgkin's lymphoma（NHL）. It is often misdiagnosed and missed diagnosis clinically. The article reports the recent findings about the morphological characteristics of peripheral blood cell smears from 1 case of MCL. Methods The clinical data and laboratory determination characteristics of the case of MCL were reviewed,retrospectively,and were analyzed with those of chronic lymphocytic leukemia. Results It was found that the morphology of lymphoma cells in the case of MCL was characterized through peripheral blood cell morphology,immunophenotype and chromosome examination. Its shape was slightly larger than those of normal small lymphocytes,and most nuclei were observed with irregularity,notch,chromatin loose,small nucleoli and cytoplasm rarely to less. Conclusions Although the diagnosis of MCL depends on lymph node biopsy,cell genetics and molecular biology,the morphology of peripheral blood cells is of significance in initial screening.

Key words: Mantle cell lymphoma, Flow cytometry, Cell morphological characteristics