Abstract:

Objective To analyze thrombelastograms（TEG） of patients treated with different antiplatelet agents,in order to provide a reference for clinical anticoagulation therapy. Methods The processes of coagulation were determined by TEG@5000 coagulation analyzer among 398 patients treated with different antiplatelet agents,including 259 elderly patients（≥65 years old） and 139 general patients（<65 years old）. Result differences between elderly patients and general patients were analyzed . Three common types of coagulation were analyzed as well. Results The main data of TEG had statistical significance between elderly patients and general patients（P<0.05）. There were 38 patients with hypercoagulability determined by TEG,and they were all elderly patients,including 23 patients with enzymatic hypercoagulability（60.53%）,9 patients with platelet hypercoagulability（23.68％） and 6 patients with enzymatic and platelet hypercoagulability（15.79%）. Conclusions Elderly patients above 65 years old treated with different antiplatelet agents are more likely to have hypercoagulability than other patients. It is essential to analyze the etiology of hypercoagulability in order to optimize clinical anticoagulation therapy and minimize the frequency of thrombosis.

Key words: Thrombelastogram, Hypercoagulability, Aspirin, Clopidogrel, Anticoagulation