Research on 12 traditional Chinese medicine pellets reversing the drug resistance of common bacteria in vitro

doi:10.3969/j.issn.1673-8640.2016.06.013

Abstract

Abstract:

Objective To investigate the antimicrobial efficiency of 12 traditional Chinese medicine pellets on 6 drug-resistant bacteria,like penicillin-resistant Streptococcus pneumoniae,meticillin-resistant Staphylococcus aureus,extended-spectrum beta-lactamases（ESBLs）-producing Enterobacteriaceae and so on. Methods The antimicrobial efficiency of 12 traditional Chinese medicine pellets was evaluated by determining minimal inhibitory concentration（MIC）,the validity of reversal drug resistance and the optimal concentration of reversal drug resistance. Results Vancomycin-resistant Enterococcus,ESBLs-producing Enterobacteriaceae and multi-resistant Acinetobacter baumannii were sensitive to gallnut,and penicillin-resistant Streptococcus pneumoniae and erythromycin-resistant hemolytic Streptococcus were sensitive to scutellaria baicalensis. Meticillin-resistant Staphylococcus aureus was sensitive to coptis chinensis. The antimicrobial efficiency of traditional Chinese medicine pellets was consistent with Chinese herb tablets as well as antibiotics（P>0.05）. Conclusions The 12 traditional Chinese medicine pellets are effective to 6 drug-resistant bacteria in different degrees. Traditional Chinese medicine pellets have antimicrobial properties.

Key words: Traditional Chinese medicine pellets, Reverse, Bacterial drug resistance

CLC Number:

R446.11

PAN Jie, MIAO Xia, LIU Qibo, DENG Limei, NIU Xinyi, LI Aiwen. Research on 12 traditional Chinese medicine pellets reversing the drug resistance of common bacteria in vitro[J]. Laboratory Medicine, 2016, 31(6): 503-508.

Figures/Tables 5

References 17

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抗菌药物	耐万古霉素肠球菌	耐甲氧西林金黄色葡萄球菌	产ESBLs 大肠埃希菌	耐青霉素肺炎链球菌	多重耐药鲍曼不动杆菌	耐红霉素溶血性链球菌
左氧氟沙星	R	I	I	S	I	S
头孢他啶	R	R	R	S	S	S
头孢噻肟	R	R	R	S	S	S
头孢唑啉	R	R	R	R	I	R
庆大霉素	R	R	R	R	I	R
亚胺培南	S	S	S	S	S	S
阿米卡星	R	R	I	R	S	I
氨苄西林-舒巴坦	R	R	R	I	S	R
克林霉素	R	S	R	I	R	R
利奈唑胺	S	S	R	S	R	S

抗菌药物	耐万古霉素肠球菌	耐甲氧西林金黄色葡萄球菌	产ESBLs 大肠埃希菌	耐青霉素肺炎链球菌	多重耐药鲍曼不动杆菌	耐红霉素溶血性链球菌
左氧氟沙星	R	I	I	S	I	S
头孢他啶	R	R	R	S	S	S
头孢噻肟	R	R	R	S	S	S
头孢唑啉	R	R	R	R	I	R
庆大霉素	R	R	R	R	I	R
亚胺培南	S	S	S	S	S	S
阿米卡星	R	R	I	R	S	I
氨苄西林-舒巴坦	R	R	R	I	S	R
克林霉素	R	S	R	I	R	R
利奈唑胺	S	S	R	S	R	S

中药名称	耐万古霉素肠球菌	耐甲氧西林金黄色葡萄球菌	产ESBLs 大肠埃希菌	耐青霉素肺炎链球菌	多重耐药鲍曼不动杆菌	耐红霉素溶血性链球菌
黄芩	25.00	3.13	12.50	3.13	12.50	50.00
黄连	6.25	1.56	100.00	25.00	50.00	100.00
黄柏	6.25	25.00	400.00	50.00	100.00	100.00
金银花	25.00	3.13	100.00	6.25	100.00	200.00
马齿苋	200.00	12.50	50.00	100.00	100.00	200.00
射干	100.00	25.00	50.00	6.25	50.00	200.00
大黄	6.25	3.13	200.00	50.00	50.00	100.00
蒲公英	200.00	50.00	25.00	25.00	100.00	100.00
五倍子	3.13	6.25	3.13	12.50	3.13	50.00
苍术	400.00	50.00	200.00	100.00	50.00	400.00
汉防己	400.00	50.00	100.00	200.00	200.00	400.00
鱼腥草	12.50	100.00	200.00	100.00	50.00	200.00

中药名称	耐万古霉素肠球菌	耐甲氧西林金黄色葡萄球菌	产ESBLs 大肠埃希菌	耐青霉素肺炎链球菌	多重耐药鲍曼不动杆菌	耐红霉素溶血性链球菌
黄芩	25.00	3.13	12.50	3.13	12.50	50.00
黄连	6.25	1.56	100.00	25.00	50.00	100.00
黄柏	6.25	25.00	400.00	50.00	100.00	100.00
金银花	25.00	3.13	100.00	6.25	100.00	200.00
马齿苋	200.00	12.50	50.00	100.00	100.00	200.00
射干	100.00	25.00	50.00	6.25	50.00	200.00
大黄	6.25	3.13	200.00	50.00	50.00	100.00
蒲公英	200.00	50.00	25.00	25.00	100.00	100.00
五倍子	3.13	6.25	3.13	12.50	3.13	50.00
苍术	400.00	50.00	200.00	100.00	50.00	400.00
汉防己	400.00	50.00	100.00	200.00	200.00	400.00
鱼腥草	12.50	100.00	200.00	100.00	50.00	200.00

中药名称	耐万古霉素肠球菌	耐甲氧西林金黄色葡萄球菌	产ESBLs 大肠埃希菌	耐青霉素肺炎链球菌	多重耐药鲍曼不动杆菌	耐红霉素溶血性链球菌
黄芩	12.50	1.56	12.50	0.78	3.13	25.00
黄连	3.13	0.78	25.00	6.25	12.50	200.00
黄柏	1.56	12.50	200.00	25.00	50.00	25.00
金银花	6.25	1.56	25.00	1.56	50.00	100.00
马齿苋	100.00	6.25	25.00	50.00	50.00	100.00
射干	50.00	12.50	25.00	3.13	25.00	100.00
大黄	1.56	0.78	100.00	12.50	25.00	50.00
蒲公英	50.00	12.50	6.25	12.50	50.00	50.00
五倍子	1.56	6.25	3.13	3.13	0.78	12.50
苍术	200.00	25.00	100.00	50.00	25.00	200.00
汉防己	200.00	12.50	25.00	100.00	100.00	200.00
鱼腥草	3.13	25.00	100.00	50.00	25.00	100.00