Significance of homocysteine and blood lipid detection in the diagnosis of sudden sensorineural hearing loss

doi:10.3969/j.issn.1673-8640.2015.09.010

Abstract

Abstract: Objective

To study the significance of homocysteine(Hcy) and blood lipid detection [total cholesterol(TC), triglyceride(TG) and low-density lipoprotein cholesterol(LDL-C)] in the diagnosis of sudden sensorineural hearing loss(SSHL).

Methods

A total of 80 patients with SSHL were enrolled, and 78 subjects without SSHL matched with SSHL group for sex, age and race were enrolled as control group. The serum levels of Hcy, TC, TG and LDL-C were detected. The relationship with SSHL was analyzed.

Results

The serum Hcy, TC, TG and LDL-C levels in SSHL group [(16.16±3.94) μmol/L, (5.38±0.99)mmol/L, 1.66(1.23-5.70)mmol/L and (3.49±0.78)mmol/L] were significantly higher than those in control group [(12.59±2.24)μmol/L, (4.51±0.91)mmol/L, 1.48(0.69-3.01)mmol/L and (2.59±0.80)mmol/L] (P<0.01). The correlation analysis showed that serum Hcy was positively correlated with TC, TG and LDL-C(r=0.669, 0.514 and 0.704, P<0.01). Logistic regression analysis showed that Hcy and LDL-C were important risk factors for SSHL[OR(95% confidence interval) were 1.85(1.256-2.725) and 4.412(1.134-17.170)]. The positive rates of Hcy and LDL-C were 47.5% and 51.3% in SSHL group and 9.0% and 14.1% in control group (P<0.01).The positive rate of the combined detection of Hcy and LDL-C was 66.3%, which was higher than any single-positive rate.

Conclusions

The combined detection of Hcy and blood lipid for SSHL has significance in preventing,diagnosing and risking assessment .

Key words: Homocysteine, Cholesterol, Low-density lipoprotein cholesterol, Sudden sensorineural hearing loss

CLC Number:

R446.1

CHEN Hong, YANG Hong, QI Guorong. Significance of homocysteine and blood lipid detection in the diagnosis of sudden sensorineural hearing loss[J]. Laboratory Medicine, 2015, 30(9): 906-910.

Figures/Tables 2

References 14

[1]	中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(8):569.
[2]	CHEN YS,EMMERLING O,ILGNER J,et al.Idiopathic sudden sensorineural hearing loss in children[J]. Int J Pediatr Otorhinolaryngol,2005,69(6):817-821.
[3]	TERANISHI M,KATAYAMA N,UCHIDA Y,et al.Thirty-year trends in sudden deafness from four nationwide epidemiological surveys in Japan[J]. Acta Otolaryngol,2007,127(12):1259-1265.
[4]	KLEMM E,DEUTSCHER A, MÖSGES R. A present investigation of the epidemiology in idiopathic sudden sensorineural hearing loss[J]. Laryngorhinootologie,2009,88(8):524-527.
[5]	MARCUCCI R,ALESSANDRELLO LIOTTA A,CELLAI AP,et al.Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss[J].J Thromb Haemost,2005,3(5): 929-934.
[6]	刘晓军,蔡东联.高同型半胱氨酸血症致动脉粥样硬化机制研究进展[J].肠外与肠内营养,2007,14(2):120-125.
[7]	李燕,张春来,卢峰,等.高同型半胱氨酸血症对平滑肌细胞的氧化损伤[J].首都医科大学学报,2012,33(2):251-254.
[8]	OROSKOVIC Z,SHEJBAL D,BICANIC G,et al.Influence of lipoproteins and fibrinogen on pathogenesis of sudden sensorineural hearing loss[J].J Laryngol Otol,2011,125(3): 258-261.
[9]	ROSSENBACH J,MUELLER GA,LANGE K,et al.Lipid-apheresis improves microcirculation of the upper limbs[J] . J Clin Apher,2011,26(4):167-173.
[10]	ORITA S,FUKUSHIMA K,ORITA Y,et al.Sudden hearing impairment combined with diabetes mellitus or hyperlipidemia[J]. Eur Arch Otorhinolaryngol,2007,264(4): 359-362.
[11]	胡可胜,马艳华,刘连红,等. 血清ox-LDL与非酒精性脂肪肝超声检查关系的探讨[J].检验医学,2014,29(2):118-121.
[12]	李宗锋,李洪臣.中年男性高脂血症患者伴发高同型半胱氨酸和高铁蛋白及高尿酸血症情况调查及分析[J].医学临床研究,2014,31(3):420-422.
[13]	WYSOKIN' SKI A,KOWMAN M,KLOSZEWSKA I. The prevalence of metabolic syndrome and Framingham cardiovascular risk scores in adult inpatients taking antipsychotics-a retrospective medical records review[J]. Psychiatr Danub,2012,24(3): 314-322.
[14]	KELLER JJ,WU CS,KANG JH,et al.Association of acute myocardial infarction with sudden sensorineural hearing loss: a population-based case-control study[J]. Audiol Neurootol,2013,18(1):3-8.

组别	例数	Hcy(μmol/L)	TC(μmol/L)	TG(μmol/L)	LDL-C(μmol/L)
SSHL 组	80	16.16±3.94	5.38±0.99	1.66(1.23~5.70)	3.49±0.70
正常对照组	78	12.86±2.24	4.51±0.91	1.48(0.69~3.01)	2.59±0.80
P值		0.000	0.000	0.006	0.000

组别	例数	Hcy(μmol/L)	TC(μmol/L)	TG(μmol/L)	LDL-C(μmol/L)
SSHL 组	80	16.16±3.94	5.38±0.99	1.66(1.23~5.70)	3.49±0.70
正常对照组	78	12.86±2.24	4.51±0.91	1.48(0.69~3.01)	2.59±0.80
P值		0.000	0.000	0.006	0.000

组别	例数	Hcy	LDL-C	Hcy + LDL-C
SSHL组	80	38(47.5)	41(51.3)	53(66.3)
正常对照组	78	7(9.0)	11(14.1)	15(19.2)
χ²值		28.7	24.68	35.62
P值		0.000	0.000	0.000

组别	例数	Hcy	LDL-C	Hcy + LDL-C
SSHL组	80	38(47.5)	41(51.3)	53(66.3)
正常对照组	78	7(9.0)	11(14.1)	15(19.2)
χ²值		28.7	24.68	35.62
P值		0.000	0.000	0.000

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