Research progress on the correlation of LTA single nucleotide polymorphism with the susceptibility of gastric cancer

doi:10.3969/j.issn.1673-8640.2014.05.004

Abstract

Abstract:

Although the morbidity and mortality of gastric cancer is on the decline around the world, it is still rising in China recently and has become one of main factors that influences on the quality of people′s life.The pathogenesis of gastric cancer is associated with various factors, involving in gene polymorphism, inflammatory cytokines, biochemical mechanisms and so on. In particular, lymphotoxin-alpha(LTA) gene single nucleotide polymorphism has been a hot spot in the research of gastric carcinogenesis in recent years.While LTA rs909253(A/G), rs1041981(C/A), rs2229094(T/C), rs746868(G/C)and so on have some associations with gastric cancer, there is no consistent result.This article reviews the current progress in the relationship between LTA gene polymorphism and the susceptibility of gastric cancer.

Key words: Lymphotoxin-alpha gene, Single nucleotide polymorphism, Gastric cancer

CLC Number:

Q753

WANG Hongling, LU Renquan, GUO Lin.. Research progress on the correlation of LTA single nucleotide polymorphism with the susceptibility of gastric cancer[J]. , 2014, 29(5): 441-445.

References

[1] Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
[2] Yang L.Incidence and mortality of gastric cancer in China [J]. World J Gastroentrol, 2006, 12(1):17-20.
[3] Smirnova AS, Ferreira-Silva KC, Mine KL, et al. Differential expression of new LTA splice variants upon lymphocyte activation[J]. Mol Immunol, 2008, 45(1):295-300.
[4] Oikari LE, Stuart S, Okolicsanyi RK, et al. Investigation of lymphotoxin α genetic variants in migraine[J]. Gene, 2013, 512(2):527-531.
[5] 殷际义, 崔正言.肿瘤坏死因子分子生物学研究进展[J]. 国外医学(免疫学分册), 1992, 15(6):311-315.
[6] Lu R, Dou X, Gao X, et al. A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population[J]. Cancer Epidemiol, 2012, 36(6):e380-e386.
[7] 黄刚, 张胜本, 蔡中琼, 等.肿瘤坏死因子对胃癌细胞增殖周期的作用研究[J].华人消化杂志, 1998, 6(S2):481.
[8] Suna S, Sakata Y, Sato H, et al. Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha:DNA microarray analysis[J]. J Atheroscler Thromb, 2008, 15(3):160-165.
[9] Takei K, Ikeda S, Arai T, et al. Lymphotoxin-alpha polymorphisms and presence of cancer in 1, 536 consecutive autopsy cases[J]. BMC Cancer, 2008, 8:235.
[10] Messer G, Spengler U, Jung MC, et al. Polymorphic structure of the tumor necrosis factor (TNF) locus:an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production[J]. J Exp Med, 1991, 173(1):209-219.
[11] Li C, Xia B, Yang Y, et al. TNF gene polymorphisms and Helicobacter Pylori infection in gastric carcinogenesis in Chinese population[J]. Am J Gastroenterol, 2005, 100(2):290-294.
[12] Fei BY, Xia B, Deng CS, et al. Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population[J]. World J Gastroenterol, 2004, 10(9):1256-1261.
[13] Guo W, Wang N, Li Y, et al. Polymorphisms in tumor necrosis factor genes and susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high incidence region of North China[J]. Chin Med J(Engl), 2005, 118(22):1870-1878.
[14] He B, Pan Y, Xu Y, et al. Increased risk for gastric cancer in carriers of the lymphotoxin-α+252G variant infected by Helicobacter pylori[J]. Genet Test Mol Biomarkers, 2012, 16(1):9-14.
[15] Oliveira JG, Duarte MC, Silva AE, et al.IL-1ra anti-inflammatory cytokine polymorphism is associated with risk of gastric cancer and chronic gastritis in a Brazilian population, but the TNF-β pro-inflammatory cytokine is not[J]. Mol Biol Rep, 2012, 39(7):7617-7625.
[16] Suzuki G, Cullings H, Fujiwara S, et al. LTA 252GG and GA genotypes are associated with diffuse-type noncardia gastric cancer risk in the Japanese population[J]. Helicobacter, 2009, 14(6):571-579.
[17] Ozaki K, Ohnishi Y, Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction[J]. Nat Genet, 2002, 32(4):650-654.
[18] Yang L, Feng R, Liu G, et al. TNF-β +252 A>G polymorphism and susceptibility to cancer[J]. J Cancer Res Clin Oncol, 2013, 139(5):765-772.
[19] Chae YS, Kim JG, Sohn SK, et al. Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP[J]. Cancer Chemother Pharmacol, 2010, 65(3):571-577.
[20] Lee SG, Kim B, Yook JH, et al. TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population[J]. Cytokine, 2004, 28(2):75-82.
[21] Crusius JB, Canzian F, Capellá G, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)[J]. Ann Oncol, 2008, 19(11):1894-1902.
[22] 肖晖.TNF、IL-10基因多态性与胃癌的相关性研究[D].武汉:武汉大学, 2009.
[23] Neo JL, Uttamchandani M. Visual DNA detection and SNP genotyping using asymmetric PCR and split DNA enzymes[J]. Methods Mol Biol, 2013, 1039:141-151.
[24] He N, Li S, Liu H. High-throughput SNP detection based on PCR amplification on magnetic nanoparticles using dual-color hybridization[J]. Methods Mol Biol, 2009, 578:393-402.
[25] Ishikawa T, Hayashizaki Y. Clinical SNP detection by the SmartAmp method[J]. Methods Mol Biol, 2013, 1015:55-69.
[26] 邢培祥, 肖东杰, 曾庆东, 等. 细胞因子基因多态性与胃腺癌发生及其临床病理特点的关系[J].中国普通外科杂志, 2006, 15(9):659-663.
[27] 周后德. 单核苷酸多态性的研究进展[J]. 国外医学(生理、病理科学与临床分册), 2003, 23(5):444-447.