Relationship between microRNA-related single nucleotide polymorphism and tumors

doi:10.3969/j.issn.1673-8640.2014.05.003

Abstract

Abstract:

MicroRNAs (miRNAs) are well-conserved small non-coding RNAs, which play roles in transcriptional and post-transcriptional regulation of gene expression. MiRNAs participate in diverse biological pathways and may act as oncogenes or tumor suppressors. Single nucleotide polymorphism(SNP) in miRNAs might promote carcinogenesis and tumor development, which may also affect early diagnosis, prognosis and treatment. Here, we highlight the association between miRNA-related SNP and tumors and describe the miRNA polymorphisms and SNP in miRNA target gene.

Key words: MicroRNA, Single nucleotide polymorphism, Tumor

CLC Number:

LIANG Qiuli, LI Shujin, NI Peihua.. Relationship between microRNA-related single nucleotide polymorphism and tumors[J]. , 2014, 29(5): 435-440.

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