BNP和NT-proBNP在新生儿心血管疾病中的应用进展

doi:10.3969/j.issn.1673-8640.2023.06.003

摘要/Abstract

摘要：

B型钠尿肽（BNP）和氨基末端B型钠尿肽原（NT-proBNP）是心肌细胞分泌的生物标志物，是反映心脏结构和功能的敏感指标。在新生儿人群中，血浆BNP和NT-proBNP水平的参考区间目前尚无统一标准，但已有较多研究探索了其在新生儿心血管疾病诊断、疗效监测和预后评估中的应用价值。文章对相关研究进展进行综述，以便为临床应用提供参考。

关键词: B型钠尿肽, 氨基末端B型钠尿肽原, 新生儿, 心血管疾病, 疗效监测, 预后

Abstract:

B-type natriuretic peptide（BNP） and N-terminal pro-B-type natriuretic peptide（NT-proBNP） are blood markers secreted by cardiomyocytes and sensitive indicators reflecting cardiac structure and function. There is no consensus on the reference ranges of plasma levels of BNP and NT-proBNP in neonates，but many studies have explored the application in the diagnosis assessment，therapeutic monitoring and prognostic evaluation for neonatal cardiovascular diseases. This review mainly summarizes the above aspects in order to provide guidance for clinical application.

Key words: B-type natriuretic peptide, N-terminal pro-B-type natriuretic peptide, Neonate, Cardiovascular disease, Therapeutic monitoring, Prognosis

中图分类号:

R446.1

尹娅, 潘沅, 周宏伟, 沈薇. BNP和NT-proBNP在新生儿心血管疾病中的应用进展[J]. 检验医学, 2023, 38(6): 518-523.

YIN Ya, PAN Yuan, ZHOU Hongwei, SHEN Wei. Application progress of BNP and NT-proBNP in neonates[J]. Laboratory Medicine, 2023, 38(6): 518-523.

图/表 3

参考文献 57

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参考文献	发表年	国家	生物标志物	例数/例	胎龄/周	日龄/d	BNP临界值/（pg/mL）	敏感性/%	特异性/%
[25]	2021年	中国	BNP	67	28~32	3	①	75.6	73.1
[26]	2021年	墨西哥	BNP	29	< 32	3~5	486.5	81.0	92.0
[27]	2013年	日本	BNP	46	<33	1~2	550.0	83.0	86.0
[28]	2012年	韩国	BNP	28	<37	4	412.0	100.0	95.0
[29]	2011年	美国	BNP	52	<34	3~7	122.5	100.0	100.0
[30]	2021年	美国	NT-proBNP	99	27.6±2.55	3	8 500.0	84.0	86.0
[31]	2012年	法国	NT-proBNP	140	<32	1~3	8 500.0	90.0	76.0
[32]	2012年	美国	NT-proBNP	69	27	3~5	5 900.0	96.0	90.0
[33]	2011年	比利时	NT-proBNP	31	<32	2/4	10 000.0/5 000.0	89.0/91.0	100.0/100.0

参考文献	发表年	国家	生物标志物	例数/例	胎龄/周	日龄/d	BNP临界值/（pg/mL）	敏感性/%	特异性/%
[25]	2021年	中国	BNP	67	28~32	3	①	75.6	73.1
[26]	2021年	墨西哥	BNP	29	< 32	3~5	486.5	81.0	92.0
[27]	2013年	日本	BNP	46	<33	1~2	550.0	83.0	86.0
[28]	2012年	韩国	BNP	28	<37	4	412.0	100.0	95.0
[29]	2011年	美国	BNP	52	<34	3~7	122.5	100.0	100.0
[30]	2021年	美国	NT-proBNP	99	27.6±2.55	3	8 500.0	84.0	86.0
[31]	2012年	法国	NT-proBNP	140	<32	1~3	8 500.0	90.0	76.0
[32]	2012年	美国	NT-proBNP	69	27	3~5	5 900.0	96.0	90.0
[33]	2011年	比利时	NT-proBNP	31	<32	2/4	10 000.0/5 000.0	89.0/91.0	100.0/100.0

参考文献	发表年	国家	生物标志物	例数/例	胎龄/周	年龄/h	BNP 临界值/（pg/mL）	敏感性/%	特异性/%
[42]	2019年	美国	BNP	128	<32	24	130	50.0	92.0
[43]	2004年	美国	BNP	47	37.4~38.5	24	550	83.0	100.0

参考文献	发表年	国家	生物标志物	例数/例	胎龄/周	年龄/h	BNP 临界值/（pg/mL）	敏感性/%	特异性/%
[42]	2019年	美国	BNP	128	<32	24	130	50.0	92.0
[43]	2004年	美国	BNP	47	37.4~38.5	24	550	83.0	100.0

参考文献	发表年	国家	生物标志物	疾病	例数/例	胎龄/周	日龄/d	BNP/（pg/mL）	敏感性/%	特异性/%
[50]	2020年	沙特阿拉伯	NT-pro BNP	CHD	20	37.20±1.36	30.0	24.5	66.0	85.0
[51]	2011年	希腊	BNP	CHD	75	<37.00	0.5~2.0	132.5	93.1	100.0
[52]	2010年	德国	BNP	CHD	152	35.00~42.00	0.0~3.0	417.0	84.0	66.0
							4.0~30.0	206.0	91.0	80.0
[53]	2009年	美国	BNP	CHD	42	36.00	1.0	170.0	94.0	73.0