关键词: 抗缪勒氏管激素, 抑制素B, 卵巢储备功能, 抗磷脂综合征

Abstract:

Objective To investigate the roles of serum anti-Müllerian hormone（AMH） and inhibin B（INHB） levels in the evaluation of ovarian reserve in females with antiphospholipid syndrome（APS） of childbearing age.Methods Totally,86 female patients with APS（APS group）,among whom 32 were primary antiphospholipid syndrome（PAPS）（PAPS group）,and 54 are secondary antiphospolipid syndrome（SAPS）（SAPS group）,were enrolled. A total of 52 female patients suffered from autoimmune diseases were enrolled as disease control group,and 50 healthy childbearing females were enrolled as healthy control group. All blood samples were collected within 2-5 d of a new menstrual cycle,which were determined for serum AMH,INHB,luteinizing hormone（LH）,follicle stimulating hormone（FSH） and estradiol（E2） levels,and antral follicle count（AFC） was conducted simultaneously by transvaginal sonography. The correlations were evaluated by Pearson correlation analysis.Results The levels of AMH,INHB,E2 and AFC in APS group and disease control group were lower than those in healthy control group（P<0.01）. AMH in SAPS group had lower results than that in PAPS group（P<0.05）. The ratio of AMH<0.9 ng/mL and the ratio of AMH<0.5 ng/mL in APS group and disease control group were higher than those in healthy control group（P<0.01）,but there was no statistical significance between APS group and disease control group（P>0.05）. In APS group,AMH was positively correlated with INHB and AFC（r values were 0.85 and 0.74,P<0.01）.Conclusions Serum AMH plays a role in the evaluation of ovarian reserve in female APS patients of childbearing age.

Key words: Anti-Müllerian hormone, Inhibin B, Ovarian reserve, Antiphospholipid syndrome