检验医学 ›› 2019, Vol. 34 ›› Issue (8): 701-703.DOI: 10.3969/j.issn.1673-8640.2019.08.006

• 临床应用研究·论著 • 上一篇    下一篇

儿童常见肿瘤骨髓转移的细胞形态学特点

王欢, 高原(), 姜林林, 张泓   

  1. 上海市儿童医院检验科,上海 200040
  • 收稿日期:2018-06-01 出版日期:2019-08-30 发布日期:2019-08-27
  • 作者简介:null

    作者简介:王欢,女,1977年生,主管技师,主要从事临床检验及细胞形态学检查工作。

  • 基金资助:
    上海市卫生和计划生育委员会重要薄弱学科建设项目(2015ZB0203)

Morphological characteristics of bone marrow metastasis in children with common tumors

WANG Huan, GAO Yuan(), JIANG Linlin, ZHANG Hong   

  1. Department of Clinical Laboratory,Shanghai Children's Hospital,Shanghai 200040,China
  • Received:2018-06-01 Online:2019-08-30 Published:2019-08-27

摘要:

目的 分析儿童常见肿瘤骨髓转移的临床表现及肿瘤细胞形态学特点,提高医务人员对疾病的诊断能力。方法 选取38例确诊肿瘤骨髓转移患儿,对其临床特征及实验室检查结果进行回顾性分析。结果 骨髓细胞形态学检查发现肿瘤骨髓转移形态学有共性,在涂片中可见数量不等的散在或成簇、成团分布的肿瘤细胞“合抱体”,并有着各自不同的形态学特点,特别是神经母细胞瘤细胞的菊团样分布和细胞周围成堆条索状物。结论 骨髓细胞学检查对肿瘤骨髓转移的诊断有指导意义,形态不典型时可结合血液生化、免疫分型等检查结果协同诊断。

关键词: 儿童, 肿瘤细胞, 骨髓转移

Abstract:

Objective To analyze the clinical features of bone marrow metastasis and the morphological characteristics of bone marrow metastasis tumor cells in children with common tumors,in order to improve the diagnosis of diseases. Methods A total of 38 children diagnosed with bone marrow metastasis were enrolled. The clinical features and the results of laboratory examinations were analyzed retrospectively. Results Bone marrow cytology revealed common morphological changes in bone marrow metastasis,and in the smear there were various amounts of scattered or clustered into tumor cells "just the distribution of body mass". However,they had different morphological characteristics,especially for chrysanthemum-like distribution of neuroblastoma cells and the piles of strips around the cells. Conclusions Bone marrow cytology is of guiding significance in the metastasis diagnosis of bone marrow tumors. Atypical morphology can be combined with other laboratory examinations for diagnosis.

Key words: Children, Tumor cell, Bone marrow metastasis

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