癌胚抗原相关黏附分子1与肿瘤

doi:10.3969/j.issn.1673-8640.2014.09.002

摘要/Abstract

摘要：

癌胚抗原相关黏附分子1(CEACAM1)又名CD66a或胆汁糖蛋白(BGP),属于免疫球蛋白超家族,广泛表达于内皮细胞、上皮细胞、粒细胞、淋巴细胞和肿瘤细胞。CEACAM1作用广泛,参与细胞间黏附、增殖、迁移、凋亡、血管生成等多种病理生理过程。在肿瘤的发生、发展中也发挥着重要作用,对肿瘤细胞生长、浸润转移、血管生成等均有调节作用。在临床上,CEACAM1有作为一种新的肿瘤标志物的良好潜能,在肿瘤的早期诊断和预后判断方面有着重要作用。本文就CEACAM1 与肿瘤的关系特别是其临床应用价值作一综述。

关键词: 癌胚抗原相关黏附分子1, 肿瘤, 预后, 诊断价值

Key words: Carcinoembryonic antigen-related cell adhesion molecule 1, Tumor, Prognosis, Diagnosis significance

中图分类号:

R446.62

杨长成,王文涓,高锋. 癌胚抗原相关黏附分子1与肿瘤[J]. 检验医学, 2014, 29(9): 877-883.

YANG Changcheng, WANG Wenjuan, GAO Feng. Carcinoembryonic antigen-related cell adhesion molecule 1 and tumor[J]. , 2014, 29(9): 877-883.

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