关键词: B族链球菌, 孕晚期, 荧光定量PCR, 带菌率

Abstract: Objective To evaluate the colonization of group B Streptococcus(GBS) in late pregnancy in Nanjing area. Methods The vaginal samples from 9 073 women in late pregnancy(34-37 weeks) were collected. A total of 500 cases of second trimester(20-24 weeks)of healthy pregnant women were chosen as control group. The colonization of GBS was detected by fluorescence quantitation polymerase chain reaction(PCR). The results were analyzed comparatively. Results The results showed that the GBS carrier rate in late pregnancy was 4.17%, the carrier rate in second trimester pregnant women was 5.20%, and there was no statistical significance between the 2 groups(P>0.05). The carrier rate of 30-34 years old group was the highest (4.77%), compared with ≤24 years old group and ≥40 years old group respectively, and the difference was statistically significant (P<0.05), but the difference with the other age groups had no statistical significance (P>0.05). Conclusions The carrier rate of GBS in late pregnancy is within the range of carrier rate of healthy population in Nanjing area. Gestational weeks have little effect on the pregnant women with GBS carrier rate

Key words: Group B Streptococcus, Late pregnancy, Fluorescence quantitation polymerase chain reaction, Colonization carrier rate