关键词: 网织红细胞血红蛋白, 低色素性红细胞百分比, 缺铁性贫血, 妊娠

Abstract: Objective　To investigate the application significance of reticulocyte hemoglobin concentration（CHr） and hypochromic red blood cell percentage（Hypo%） for the screening of iron deficiency anemia（IDA）during pregnancy.   Methods　The levels of red blood cell（RBC），hemoglobin（Hb），mean corpuscular volume（MCV），mean corpuscular hemoglobin（MCH），mean corpuscular hemoglobin concentration（MCHC），Hypo%，red cell volume distribution width（RDW），CHr and the percentage of reticulocyte（Ret%） in peripheral blood of pregnant women were determined by ADVIA2120 hematology analyzer. The levels of serum iron（SI） were measured simultaneously. Results　The levels of CHr，RBC，Hb，MCV，MCH，MCHC，Hypo%，RDW and SI in IDA group had statistical significance compared with those in non-IDA group and normal group（P＜0.05）. Ret% had no statistical significance（P＞0.05）. The levels of CHr and Hypo% in IDA group were（26.8±3.4）pg and（7.5±3.7）%，which had statistical significance with those of non-IDA group [CHr（31.9±2.4）pg and Hypo%（1.6±1.6）%] and normal group [CHr（33.9±2.2） pg and Hypo%（0.7±0.8） %，P＜0.01]. When the cut-off value was 29.0 pg，the sensitivity of CHr was 81.0%，the specificity was 93.0%，and the area under receiver operating characteristic（ROC） curve was 0.929. When the cut-off value was 6%，the sensitivity of Hypo% was 78.0%，the specificity was 95.0%，and the area under ROC curve was 0.933. Conclusions　The determination of CHr and Hypo% can be used as sensitive and early indices in the diagnosis of IDA in pregnant women. The simultaneous detection of CHr and Hypo% can provide scientific reference for nutrition intaking in pregnant women.

Key words: Reticulocyte hemoglobin, Hypochromic red blood cell percentage, Iron deficiency anemia, Pregnancy