关键词: 帕金森病蛋白7, 可溶性髓系细胞触发受体样转录物1, 重症肺炎, 呼吸衰竭, 预后

Abstract:

Objective To investigate the role of serum Parkinson's disease protein 7（PARK7） and soluble triggering receptor expressed on myeloid cell-like transcript-1（sTLT-1） in the short-term prognosis assessment of patients with severe pneumonia complicated by respiratory failure. Methods A total of 238 patients with severe pneumonia complicated by respiratory failure（respiratory failure group），185 patients with simple severe pneumonia（simple pneumonia group） and 185 healthy subjects（healthy control group） were enrolled from the First Hospital of Handan City from January 2022 to March 2025. The patients with severe pneumonia complicated by respiratory failure were classified into mild（0-10 points） group（65 cases），moderate（11-20 points） group（105 cases） and severe（>20 points） group（68 cases） according to the acute physiology and chronic health evaluation Ⅱ（APACHE Ⅱ） score. The patients with severe pneumonia complicated by respiratory failure were classified into survival group（175 cases） and death group（63 cases） according to their survival status within 28 d after admission. The clinical data were collected. The laboratory routine indicators and serum PARK7 and sTLT-1levels were determined，and the difference of each indicator was compared. Pearson correlation analysis was used to evaluate the correlation between various indicators. Cox regression analysis was used to evaluate the influencing factors of death in patients with severe pneumonia complicated by respiratory failure. Receiver operating characteristic（ROC） curve was used to evaluate the efficacy of PARK7 and sTLT-1 in judging the death of patients with severe pneumonia complicated by respiratory failure. Results The serum PARK7 and sTLT-1 levels in healthy control group，simple pneumonia group and respiratory failure group were increased successively（P<0.05）. There was no statistical significance in the other indicators among the groups（P>0.05）. The serum PARK7 and sTLT-1 levels in the mild group，moderate group and severe group were increased successively（P<0.05），and there was no statistical significance in the other indicators among the groups（P>0.05）. The intensive care unit（ICU） hospitalization time，APACHE Ⅱ score，white blood cell（WBC） count，C-reactive protein（CRP），PARK7 and sTLT-1 levels in death group were higher than those in survival group（P<0.05），and the differences in the other indicators among the groups were not statistically significant（P>0.05）. The serum PARK7 and sTLT-1 levels of patients with severe pneumonia complicated by respiratory failure were positively correlated with CRP and WBC count（P<0.05）. Elevated APACHE Ⅱ score，CRP，WBC count，PARK7 and sTLT-1 levels were independent risk factors for death（P<0.05）. The areas under curves（AUC） of single and combined determinations of serum PARK7 and sTLT-1 for judging the death of patients with severe pneumonia complicated by respiratory failure were 0.776，0.787 and 0.853，respectively. Conclusions Serum PARK7 and sTLT-1 have high value in the short-term prognosis assessment of patients with severe pneumonia complicated by respiratory failure，and they may be used as prognostic indicators.

Key words: Parkinson's disease protein 7, Soluble triggering receptor expressed on myeloid cell-like transcript-1, Severe pneumonia, Respiratory failure, Prognosis