空腹血清游离脂肪酸与2型糖尿病的关系

检验医学 ›› 2012, Vol. 27 ›› Issue (9): 725-727.

空腹血清游离脂肪酸与2型糖尿病的关系

陆秋涯,迟贞旎,陆怡德

上海交通大学医学院附属瑞金医院检验科，上海 200025

收稿日期:2012-07-04 出版日期:2012-09-12 发布日期:2012-09-12
作者简介:陆秋涯，男，1978年生，硕士，主管技师，主要从事临床实验诊断研究。

The relationship of fasting serum free fatty acid and type 2 diabetes mellitus

Department of Clinical Laboratory，Ruijin Hospital，Shanghai Jiaotong University School of Medicine，Shanghai 200025，China

Received:2012-07-04 Online:2012-09-12 Published:2012-09-12

摘要/Abstract

摘要： 目的　2型糖尿病（T2DM）患者血清游离脂肪酸（FFA）水平的变化及与糖代谢、胰岛素抵抗各指标间的相关性，并探讨影响T2DM的危险因素。方法　通过口服糖耐量试验(OGTT)筛选105例未经药物治疗的T2DM患者和66名健康人（正常对照组），分别测定其血浆葡萄糖(PG)和胰岛素(Ins)水平，计算胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-IS)，同时检测空腹血清FFA。对血清FFA浓度与性别、年龄、体重、体重指数(BMI)、0～3 h PG和Ins以及HOMA-IR、HOMA-IS进行相关性分析。以T2DM是否发病为因变量Y（T2DM组=1，正常对照组=0），性别、年龄、体重、BMI、HOMA-IR、HOMA-IS和FFA为自变量，做Logistic回归分析。结果　T2DM组HOMA-IR、HOMA-IS和血清FFA水平与正常对照组比较差异均有统计学意义（P＜0.01、P＜0.001）。相关分析发现，空腹血清FFA与0 h PG、0.5 h PG、1 h PG、2 h PG、3 h PG、3 h Ins、HOMA-IR呈弱正相关（r分别为0.340、0.281、0.282、0.307、0.302、0.193、0.225，P均<0.05）。Logistic回归分析显示血清FFA是T2DM的重要风险因素[OR=14.05，95%可信区间（CI）：1.87～105.55]。结论　血清FFA水平升高可能影响机体糖动态平衡，与胰岛素抵抗和T2DM发病密切相关。

关键词: 游离脂肪酸, 2型糖尿病, 胰岛素抵抗

Abstract: Objective　To investigate the correlation of serum free fatty acid (FFA) levels in patients with type 2 diabetes mellitus(T2DM) with the parameters of glucose metabolism and insulin resistance，and study the risk factors of T2DM. Methods　A total of 105 patients with T2DM and 66 healthy controls (normal control group) were screened and classified into 2 groups by oral glucose tolerance test (OGTT). The plasma glucose (PG)，serum insulin (Ins) and fasting serum FFA were measured. The HOMA-insulin resistance index (HOMA-IR) and HOMA-insulin secretion index (HOMA-IS) were calculated. The correlations of serum FFA with sex，age，weight，body mass index(BMI)，0-3 h PG and Ins，HOMA-IR and HOMA-IS were analyzed. Logistic regression analysis was used with sex，age，weight，BMI，HOMA-IR，HOMA-IS and FFA to define the independent risk factors of T2DM，and variance Y was according to T2DM group=1 and normal control group=0. Results　HOMA-IR，HOMA-IS and fasting serum FFA had significant difference between T2DM group and normal control group (P<0.01，P<0.001). The correlation analysis showed that fasting serum FFA level was positively correlated with 0 h PG，0.5 h PG，1 h PG，2 h PG，3 h PG，3 h Ins and HOMA-IR (r=0.340，0.281，0.282，0.307，0.302，0.193 and 0.225，P<0.05). The Logistic regression analysis showed that fasting serum FFA level was the important risk factor of T2DM[odd ratio (OR)= 14.05，95% confidence interval (CI): 1.87-105.55]. Conclusions　The increasing of fasting serum FFA level may be related to glucose homeostasis，insulin resistance and T2DM development.

Key words: Free fatty acid, Type 2 diabetes mellitus, Insulin resistance

陆秋涯;迟贞旎;陆怡德. 空腹血清游离脂肪酸与2型糖尿病的关系[J]. 检验医学, 2012, 27(9): 725-727.

LU Qiuya;CHI Zhenni;LU Yide. The relationship of fasting serum free fatty acid and type 2 diabetes mellitus[J]. , 2012, 27(9): 725-727.

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