中性粒细胞明胶酶相关脂质运载蛋白的研究进展

摘要/Abstract

摘要： 中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associated lipocalin，NGAL）又称为脂质运载蛋白-2（lipocalin-2，Lcn-2）或噬铁蛋白（siderocalin），是lipocalin家族的成员之一。1993年，Kjeldsen等^[1]在研究人类中性粒细胞92 000明胶酶B[即基质金属蛋白酶9（MMP-9）]时发现，在培养的活化中性粒细胞的上清液中存在NGAL。随后，NGAL cDNA及全基因序列分别于1994年和1997年被克隆鉴定^[2-3]。多年来，对NGAL的蛋白空间结构研究也进一步明确了其生物学功能，特别是以此为基础的各种临床研究，也越来越多显示出NGAL在各种疾病中的价值。NGAL是一种新型的分泌型蛋白，其功能强大，其与炎症、免疫反应、细胞分化、细胞凋亡、组织重构及多种肿瘤的发生与发展等密切相关。自此，NGAL的结构与功能研究进展越来越受人瞩目，也越来越显示其在各种疾病诊疗中的作用，我们对此进行了综述。

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须静，胡晓波. 中性粒细胞明胶酶相关脂质运载蛋白的研究进展[J]. 检验医学, 2012, 27(10): 871-876.

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