恒定自然杀伤T细胞在过敏性哮喘中的调节机制

检验医学 ›› 2012, Vol. 27 ›› Issue (10): 866-870.

恒定自然杀伤T细胞在过敏性哮喘中的调节机制

林文¹,李莉²

收稿日期:2012-07-24 出版日期:2012-10-30 发布日期:2012-10-12
通讯作者: 李莉，联系电话：021-63240090-4306。
作者简介:林文，女，1982年生，学士，技师，主要从事临床检验工作。
基金资助:
国家自然科学基金资助项目（81072448，30972824）；上海市科委课题资助项目（10495810200）

上海交通大学附属第一人民医院检验科，上海 200080

Received:2012-07-24 Online:2012-10-30 Published:2012-10-12

摘要/Abstract

摘要： 恒定自然杀伤T (invariant nature killer T，iNKT ) 细胞是T淋巴细胞中独特的亚群，也是经典的自然杀伤T（NKT）细胞，既表达T细胞的表面标志，又表达自然杀伤（NK）细胞的表面标志CD161(NK1.1) 分子和NK细胞受体P1C。活化iNKT的经典抗原是糖脂类抗原α-半乳糖神经酰胺(α-galactosylceramide，α-GalCer)，该抗原由作用类似于主要组织相容性复合物(MHC)Ⅰ类分子的CD1d提呈给iNKT并使之活化。活化的iNKT分泌白细胞介素4（IL-4）、γ干扰素（IFN-γ）、白细胞介素10（IL-10）、白细胞介素13（IL-13）等多种细胞因子，在抗肿瘤、抗感染、抑制自身免疫性疾病及移植耐受中发挥重要作用。最近，iNKT细胞在小鼠哮喘模型和哮喘患者中的重要作用相继被报道。

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关键词: 恒定自然杀伤T细胞, CD1d , α-半乳糖神经酰胺, 过敏性哮喘

林文综述，李莉审校. 恒定自然杀伤T细胞在过敏性哮喘中的调节机制[J]. 检验医学, 2012, 27(10): 866-870.

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