不规则抗体导致ABO正反定型不符处理探讨

检验医学 ›› 2012, Vol. 27 ›› Issue (10): 822-824.

• 临床检验与血液学检验论著 • 上一篇下一篇

不规则抗体导致ABO正反定型不符处理探讨

樊凤艳¹,王洪波¹,魏少平¹,魏利召²,刘晓莉²,祁术元¹

1. 空军总医院输血科，北京100142；2. 空军总医院临床检验中心，北京100142

收稿日期:2012-07-09 修回日期:2012-08-02 出版日期:2012-10-30 发布日期:2012-10-12
作者简介:樊凤艳，女，1976年生，硕士，主治医师，主要从事临床输血检验工作。

Analysis on irregular antibody inducing unconformity of forward and reverse ABO blood typing

1. Department of Blood Transfusion，General Hospital of Air-force，Beijing 100142，China; 2. Center of Clinical Laboratory，General Hospital of Air-force，Beijing 100142, China

Received:2012-07-09 Revised:2012-08-02 Online:2012-10-30 Published:2012-10-12

摘要/Abstract

摘要： 目的　探讨不规则抗体导致ABO正反定型不符原因，并提出解决方法。方法　总结分析12例不规则抗体导致ABO正反定型不符血型血清学试验结果，通过不规则抗体筛查、不规则抗体鉴定、相应血型检测明确不规则抗体导致ABO正反定型不符确切原因，用相应抗原阴性红细胞重新进行ABO血型反定型。结果　12例标本中抗-M 4例，抗-N 1例，抗-M合并抗-N 1例，抗-Le^a 1例，抗-P₁ 1例，抗-I 1例，抗-D 1例，抗-E 1例，抗-A₁ 1例。用相应抗原阴性红细胞重新进行ABO血型反定型，正反定型结果均相符。结论　不规则抗体是导致ABO正反定型不符的常见原因，经过适当处理可以正确鉴定ABO血型。

Abstract: Objective　To investigate the factors of inducing the unconformity of forward and reverse ABO blood typing caused by irregular antibody. Methods　　The results of serological tests of blood typing in 12 cases were analyzed, and the factors of irregular antibody inducing the unconformity of forward and reverse ABO blood typing were tested for irregular antibody screening and identification and corresponding blood typing determination. Reverse ABO blood typing were repeated with red blood cells which corresponding antigens were negative. Results　The amounts of alloantibodies among 12 patients were 4 anti-M，1 anti-N，1 anti-M combined anti-N，1 anti- Le^a，1 anti- P₁，1 anti-I，1 anti-D，1 anti-E and 1 anti-A₁. The result of repeated reverse blood typing with corresponding antigens being negative blood cells matched forward blood typing. Conclusions　Samples with unconformity of forward and reverse ABO blood typing caused by irregular antibody can be identified correctly.

Key words: Blood typing, Irregular antibody, Antibody screening, Antibody identification

樊凤艳1，王洪波1，魏少平1，魏利召2，刘晓莉2，祁术元1. 不规则抗体导致ABO正反定型不符处理探讨[J]. 检验医学, 2012, 27(10): 822-824.

FAN Fengyan 1，WANG Hongbo 1，WEI Shaoping 1，WEI Lizhao 2，LIU Xiaol 2，QI Shuyuan 1. Analysis on irregular antibody inducing unconformity of forward and reverse ABO blood typing[J]. , 2012, 27(10): 822-824.

不规则抗体导致ABO正反定型不符处理探讨

Analysis on irregular antibody inducing unconformity of forward and reverse ABO blood typing

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