关键词: β-淀粉样多肽（1-42）, Tau 蛋白, 脂蛋白相关磷脂酶A2, 脑电图, 轻度认知功能障碍

Abstract:

Objective To investigate the changes of serum amyloid β-protien（Aβ）1-42，Tau protein，lipoprotein-related phospholipase A2（Lp-PLA2） and electroencephalogram parameters in patients with mild cognitive impairment（MCI）. Methods Totally，80 elderly MCI patients，80 Alzheimer’s disease（AD） patients and 80 healthy subjects（healthy control group） were enrolled. The general data were collected，and serum Aβ1-42，Tau，Lp-PLA2 levels and electroencephalogram were determined and performed. The result difference was compared. The correlations between the indicators were assessed by Pearson correlation analysis. Results Serum Aβ1-42 levels were increased successively in AD，MCI and healthy control groups（P<0.05），and serum Tau and Lp-PLA2 levels were decreased successively（P<0.05）. The α1 waves，δ waves and θ waves in MCI and AD groups were higher than those in healthy control group（P<0.05）. The δ wave and θ wave in AD group were higher than those in MCI group（P<0.05）. The α2 wave，β1 wave and β2 wave had no statistical significance among the 3 groups（P>0.05）. Pearson correlation analysis showed that δ wave and θ wave were negatively correlated with Aβ1-42（r values were -0.447 and -0.482，P=0.001 and P<0.000 1，respectively），they were positively correlated with Tau（r values were 0.571 and 0.467，P<0.000 1，respectively），and there was no correlation with Lp-PLA2 levels（r values were 0.117 and 0.163，P>0.05，respectively）. Conclusions The Aβ1-42，Tau and Lp-PLA2 levels may change abnormally in elderly MCI patients，and it may affect the electroencephalogram parameters.

Key words: Amyloid β-protein 1-42, Tau, Lipoprotein-related phospholipase A2, Electroencephalogram, Mild cognitive impairment