钙校正计算公式与离子钙检测的临床应用现状

doi:10.3969/j.issn.1673-8640.2016.07.019

检验医学 ›› 2016, Vol. 31 ›› Issue (7): 623-626.DOI: 10.3969/j.issn.1673-8640.2016.07.019

钙校正计算公式与离子钙检测的临床应用现状

吴炯, 潘柏申

复旦大学附属中山医院检验科,上海 200032

收稿日期:2015-02-06 出版日期:2016-07-30 发布日期:2016-08-10
作者简介:null
作者简介：吴炯,男,1976年生,硕士,主管技师,主要从事临床生化检测工作。

通讯作者：潘柏申,联系电话：021-64041990-2376。
基金资助:
国家临床重点检验专科建设项目资助

Status of clinical application of ionized calcium determination and corrected calcium concentration equation

WU Jiong, PAN Baishen

Department of Clinical Laboratory, Zhongshan Hospital, Fudan University, Shanghai 200032,China

Received:2015-02-06 Online:2016-07-30 Published:2016-08-10

摘要/Abstract

摘要：

总钙由离子钙和没有生理活性的钙（大部分与白蛋白结合,小部分与碳酸氢盐、柠檬酸盐和乳酸盐结合）组成。由于离子钙和总钙都可应用于临床且各有优劣,所以正确地评估患者的钙水平并非易事。与离子钙相比,总钙的检测相对简便,因此总钙测定也更广泛地应用于临床实验室。但一些临床情况下总钙不能准确地反映钙水平。文章综述了钙校正计算公式、离子钙及总钙的临床应用现状。

关键词: 总钙, 离子钙, 钙校正计算公式

Abstract:

Total calcium is consisted of ionized calcium and physiologically inactive calcium（mainly associated with albumin,as well as bicarbonate,citrate and lactate）. Monitoring patients' calcium status is not straightforward, because both ionized and total calcium determinations are commonly available for clinical interpretation,and each has advantages and disadvantages. Total calcium is more convenient to be measured than ionized calcium,and is more frequently used by clinical laboratories. However,total calcium can not represent patients' calcium status correctly in some specific clinical situations. This review focuses on the research status of corrected calcium concentration equation,ionized calcium and total calcium.

Key words: Total calcium, Ionized calcium, Corrected calcium concentration equation

中图分类号:

R446.1

吴炯, 潘柏申. 钙校正计算公式与离子钙检测的临床应用现状[J]. 检验医学, 2016, 31(7): 623-626.

WU Jiong, PAN Baishen. Status of clinical application of ionized calcium determination and corrected calcium concentration equation[J]. Laboratory Medicine, 2016, 31(7): 623-626.

图/表 1

参考文献 11

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首次报道研究者	首次报道时间	计算公式
Mondified Orell	不详	cCa=tCa+0.8×（4-Alb）
Dent	1962	cCa=tCa-0.675×（TP-7.2）
Parfitt	1969	cCa=tCa/（0.6+0.0541×TP）
Moore	1970	cCa=tCa-4×[0.001 9×Alb-0.42×Alb/473×（7.42-pH）+0.000 4×（TP-Alb）- 0.42×（TP-Alb）/250×（7.42-pH）]
Orrell	1971	cCa=tCa-0.707×（Alb-3.4）
Husdan	1973	cCa=tCa/（0.6+0.051 5×TP）
Berry	1973	cCa=tCa-0.91×（Alb-4.6）
Payne	1973	cCa=tCa-（0.989×Alb）+4
Ryan	1973	cCa=tCa+0.72×（4-Alb）
Pain	1975	cCa=tCa+（4-Alb）
Christiansen	1975	cCa=tCa/（0.6+0.05×TP）
Kelly	1976	cCa=（tCa -6）/0.05×TP
Walker	1979	cCa=tCa+0.92×（4-Alb）
Thode	1989	cCa=tCa×2.7/（1.7+Alb/4.2）
Ferrari*	2009	cCa=tCa+0.015×（40-Alb）+0.07×（1.5-P）
Zeisler	1954	iCa= [6×tCa-TP/3/（TP+6）]/40.08
Hanna	1964	iCa=11.8×t Ca/（11.8+TP）/4
Pottgen	1976	iCa= [6×tCa-（0.19×TP+Alb）/3]/（0.19×TP+Alb+6）
Fenton	1983	iCa=（0.58×tCa-0.28×Alb+2.5）×10/40.08
Forster	1985	iCa= [0.9+（0.55×tCa）-（0.3×Alb）]/4
Nordin	1989	iCa=tCa/4-0.061 3×tCa×Alb-0.024 4×tCa×（TP-Alb）-0.004 3× tCa×AG- 0.003 75×tCa×tCO₂

首次报道研究者	首次报道时间	计算公式
Mondified Orell	不详	cCa=tCa+0.8×（4-Alb）
Dent	1962	cCa=tCa-0.675×（TP-7.2）
Parfitt	1969	cCa=tCa/（0.6+0.0541×TP）
Moore	1970	cCa=tCa-4×[0.001 9×Alb-0.42×Alb/473×（7.42-pH）+0.000 4×（TP-Alb）- 0.42×（TP-Alb）/250×（7.42-pH）]
Orrell	1971	cCa=tCa-0.707×（Alb-3.4）
Husdan	1973	cCa=tCa/（0.6+0.051 5×TP）
Berry	1973	cCa=tCa-0.91×（Alb-4.6）
Payne	1973	cCa=tCa-（0.989×Alb）+4
Ryan	1973	cCa=tCa+0.72×（4-Alb）
Pain	1975	cCa=tCa+（4-Alb）
Christiansen	1975	cCa=tCa/（0.6+0.05×TP）
Kelly	1976	cCa=（tCa -6）/0.05×TP
Walker	1979	cCa=tCa+0.92×（4-Alb）
Thode	1989	cCa=tCa×2.7/（1.7+Alb/4.2）
Ferrari*	2009	cCa=tCa+0.015×（40-Alb）+0.07×（1.5-P）
Zeisler	1954	iCa= [6×tCa-TP/3/（TP+6）]/40.08
Hanna	1964	iCa=11.8×t Ca/（11.8+TP）/4
Pottgen	1976	iCa= [6×tCa-（0.19×TP+Alb）/3]/（0.19×TP+Alb+6）
Fenton	1983	iCa=（0.58×tCa-0.28×Alb+2.5）×10/40.08
Forster	1985	iCa= [0.9+（0.55×tCa）-（0.3×Alb）]/4
Nordin	1989	iCa=tCa/4-0.061 3×tCa×Alb-0.024 4×tCa×（TP-Alb）-0.004 3× tCa×AG- 0.003 75×tCa×tCO₂

钙校正计算公式与离子钙检测的临床应用现状

Status of clinical application of ionized calcium determination and corrected calcium concentration equation

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