关键词: 布鲁菌, 人布鲁菌病, 流行病学分析

Abstract:

Objective To analyze the epidemic status of human brucellosis in the southwest of Shandong Province,and to provide a reference for prevention and control. Methods The isolates of Brucella were cultured by BacT ALERT 3D120 and identified by VITEK 2 Compact. The epidemiological analysis was performed with the case histories of patients. SPSS 17.0 software was used for statistical analysis. Results In 94 patients,there were 72 males（76.6%） and 22 females（23.4%）. The ratio of males to females was 3.27∶1. The ages were from 2 to 77 years,and 68.1% of them were 30-60 years old. There were 76 patients（80.9%） in Jining,mainly from Zoucheng City and Jiaxiang County. There were 18 patients（19.1%） in Heze,mainly from Juye County and Yuncheng County. There were 81 peasants（86.2%）in 94 patients,and 59 patients of them（62.8%）had contact with goats. The occurrence rate was 54.3% from April to June. The patients with respiratory tract infection accounted for 56.5%. There were some high indices,including alanine aminotransferase（ALT）（61 cases）,aspartate aminotransferase（AST）（59 cases）,C-reactive protein（CRP）（72 cases）and procalcitonin（PCT）（64 cases）. The positive alarm always happened in oxygen bottles on the 2nd-5th days. The identification rate of Brucella melitensis was 91%-99%. The rates for therapies with rifampin,doxycycline,levofloxacin and minocycline were 100.0%,68.1%,44.7% and 31.9%,respectively. Conclusions In the southwest of Shandong Province,human brucellosis is scattered,and there is an increasing trend. The detection of Brucella and clinical analysis of human brucellosis are important for the prevention and treatment of diseases and epidemiological analysis.

Key words: Brucella, Human brucellosis, Epidemiological analysis