抗氨甲酰化蛋白抗体的研究进展

doi:10.3969/j.issn.1673-8640.2015.08.020

检验医学 ›› 2015, Vol. 30 ›› Issue (8): 857-860.DOI: 10.3969/j.issn.1673-8640.2015.08.020

抗氨甲酰化蛋白抗体的研究进展

陈燚琼, 赵迪, 李智

上海市杨浦区中心医院检验科,上海 200090

收稿日期:2014-09-10 出版日期:2015-08-30 发布日期:2015-08-28
作者简介:null
作者简介:陈燚琼,女,1983年生,硕士,主管技师,主要从事自身免疫性疾病的实验诊断研究。

通讯作者:李智,联系电话:021-65690520-333。
基金资助:
上海市杨浦区卫计委“百医登高”人才培养计划

The progress of anti-carbamylated protein antibody

CHEN Yiqiong, ZHAO Di, LI Zhi.

Department of Clinical Laboratory, Shanghai Yangpu District Central Hospital, Shanghai 200090, China

Received:2014-09-10 Online:2015-08-30 Published:2015-08-28

摘要/Abstract

摘要：

类风湿性关节炎(RA)诊治的关键是早期诊断、早期治疗,因而找寻敏感而又特异的生物学标志物成为RA早期实验诊断的迫切需要。近年来,抗氨甲酰化蛋白(CarP)抗体受到关注。抗Carp抗体可提高抗瓜氨酸蛋白抗体(ACPA)阴性RA患者的敏感性,约30% ACPA阴性RA患者能检测到该抗体。与ACPA一样,抗CarP抗体有望成为RA早期诊断的指标之一。文章就相关研究进展作一综述。

关键词: 抗氨甲酰化蛋白抗体, 类风湿性关节炎, 自身抗体

Abstract:

The key to the treatment of rheumatoid arthritis(RA) is early diagnosis and treatment. It becomes urgent to find sensitive and specific biomarkers for the early diagnosis of RA. In recent years, anti-carbamylated protein (Carp) antibody is attention. Anti-Carp antibody can improve the susceptibility of anti-citrullinated protein antibody (ACPA)-negative RA patients, and the anti-Carp antibody presents in about 30% ACPA-negative RA patients. Like ACPA, anti-Carp antibody is also a biomarker for the early diagnosis of RA. This paper will give a review of the progress.

Key words: Anti-carbamylated protein antibody, Rheumatoid arthritis, Auto-antibody

中图分类号:

R446.62

陈燚琼, 赵迪, 李智. 抗氨甲酰化蛋白抗体的研究进展[J]. 检验医学, 2015, 30(8): 857-860.

CHEN Yiqiong, ZHAO Di, LI Zhi.. The progress of anti-carbamylated protein antibody[J]. Laboratory Medicine, 2015, 30(8): 857-860.

图/表 1

参考文献 25

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抗氨甲酰化蛋白抗体的研究进展

The progress of anti-carbamylated protein antibody

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