血清顶体蛋白酶抗体与精子蛋白17抗体对不孕不育症的临床价值探讨

doi:10.3969/j.issn.1673-8640.2013.04.005

检验医学 ›› 2013, Vol. 28 ›› Issue (4): 276-279.DOI: 10.3969/j.issn.1673-8640.2013.04.005

血清顶体蛋白酶抗体与精子蛋白17抗体对不孕不育症的临床价值探讨

钟志敏

广州市第一人民医院检验科，广东广州 510180

收稿日期:2012-10-18 修回日期:2012-11-30 出版日期:2013-04-30 发布日期:2013-04-05
作者简介:钟志敏，女，1971年生，学士，副主任技师，主要从事临床免疫学工作。
基金资助:
广东省科技厅资助项目（2010B080702018）；广州市卫生局重点项目（201102A212028）

Investigation on the clinical significance of serum anti-acrosin antibodies and anti-sperm protein 17 antibodies in infertility

Department of Clinical Laboratory, Guangzhou First People′s Hospital， Guangdong Guangzhou 510180，China

Received:2012-10-18 Revised:2012-11-30 Online:2013-04-30 Published:2013-04-05

摘要/Abstract

摘要： 目的　探讨血清顶体蛋白酶抗体（AcrAb）与精子蛋白17抗体（Sp17Ab）对不孕不育的影响及意义。方法　采用酶联免疫吸附试验（ELISA）检测60例不明原因不孕不育症患者及48名正常生育者（对照组）血清AcrAb、SP17Ab。采用t检验相关分析采用直线相关分析。结果　不明原因不孕不育症组男性及女性血清AcrAb分别为（22.39±3.15）、（21.02±3.56）U/L，均明显高于对照组男、女性[（11.29±2.15）、（10.23±2.12）U/L，P＜0.01]；不明原因不孕不育症组男性及女性血清Sp17Ab分别为（10.47±2.10）、（9.63±2.04）U/L，均高于对照组男、女性[（3.63±1.05）、（3.58±1.03）U/L，P＜0.01]；男性及女性血清AcrAb和Sp17Ab之间均无相关性[相关系数（r）分别为0.17、-0.20，P均＞0.05]。结论　不明原因不孕不育症患者血清AcrAb及Sp17Ab含量明显高于正常人，且相互独立，可单独或联合检测作为不孕不育症的辅助诊断指标。

关键词: 顶体蛋白酶抗体, 精子蛋白17抗体, 不孕不育

Abstract: Objective　To investigate the influence and significance of serum anti-acrosin antibodies (AcrAb) and anti-sperm protein 17 antibodies(Sp17Ab) in infertility. Methods　The levels of serum AcrAb and Sp17Ab were detected by enzyme-linked immunosorbent assay (ELISA) in 60 patients with unexplained infertility and 48 healthy subjects(control group). The results were analyzed by t test and straight line related analysis. Results　The levels of serum AcrAb in males and females were (22.39±3.15) and (21.02±3.56）U/L in the unexplained infertility group, which were significantly higher than those in the control group [(11.29±2.15) and （10.23±2.12）U/L，P＜0.01]. The levels of serum Sp17Ab in males and females were （10.47±2.10） and （9.63±2.04）U/L in the unexplained infertility group, which were significantly higher than those in the control group [3.63±1.05 and （3.58±1.03）U/L，P＜0.01]. There was no correlation of serum AcrAb with Sp17Ab in males and females [coefficient of correlation (r) = 0.17 and -0.20, P＞0.05]. Conclusions　The levels of serum AcrAb and Sp17Ab in patients with infertility are obviously higher than those in the healthy subjects，and they are independent and can be alone or jointly detected as the indicators of infertility auxiliary diagnosis.

Key words: Anti-acrosin antibody, Anti-sperm protein 17 antibody, Infertility

钟志敏，王维，莫云丹，戴卉. 血清顶体蛋白酶抗体与精子蛋白17抗体对不孕不育症的临床价值探讨[J]. 检验医学, 2013, 28(4): 276-279.

ZHONG Zhimin，WANG Wei，MO Yundan，DAI Hui. Investigation on the clinical significance of serum anti-acrosin antibodies and anti-sperm protein 17 antibodies in infertility[J]. , 2013, 28(4): 276-279.

血清顶体蛋白酶抗体与精子蛋白17抗体对不孕不育症的临床价值探讨

Investigation on the clinical significance of serum anti-acrosin antibodies and anti-sperm protein 17 antibodies in infertility

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