诱骗受体3在HBeAg阴性的慢性乙型肝炎患者中的表达及意义

doi:10.3969/j.issn.1673-8640.2013.01.009

检验医学 ›› 2013, Vol. 28 ›› Issue (1): 37-39.DOI: 10.3969/j.issn.1673-8640.2013.01.009

诱骗受体3在HBeAg阴性的慢性乙型肝炎患者中的表达及意义

1. 上海市松江区中心医院中心实验室，上海 201600；2. 美国佛罗里达大学肿瘤研究中心，美国佛罗里达 32610

出版日期:2013-01-30 发布日期:2013-01-10
作者简介:侯彦强，男，1971年生，博士，副主任技师，主要从事临床感染免疫基础及检验研究。
基金资助:
上海市科委科研课题资助项目（12ZR142800）

Expression and significance of decoy receptor 3 in HBeAg negative chronic hepatitis B patients

Department of Central Laboratory，Songjiang Central Hospital，Shanghai 201600，China；2. Shands Cancer Center，University of Florida，Florida 32610，U.S.A

Online:2013-01-30 Published:2013-01-10

摘要/Abstract

摘要： 目的　探讨诱骗受体3（DcR3）在乙型肝炎病毒(HBV)e抗原（HBeAg）阴性的慢性乙型肝炎(CHB)患者中的表达及意义。方法　采用酶联免疫吸附试验（ELISA）检测80例血清HBeAg阴性的CHB患者和96名正常人血清DcR3；全自动生化分析仪检测丙氨酸氨基转移酶（ALT）；聚合酶链反应（PCR）检测HBV DNA。结果　HBeAg阴性的CHB患者血清DcR3水平[1.58(0.48～3.23）ng/mL]明显高于正常对照组[0.83(0.16～2.32）ng/mL，P＜0.000 1)]。HBeAg阴性的CHB患者血清DcR3水平与HBV DNA和ALT水平呈正相关（r＝0.704、0.732，P均＜0.000 1）。结论　DcR3在HBeAg阴性的CHB患者中高表达，并与HBV DNA和ALT强相关，具有潜在的作为HBeAg阴性CHB患者诊断、治疗观测的新指标的应用价值。

关键词: 诱骗受体3, 慢性乙型肝炎, 丙氨酸氨基转移酶, DNA

Abstract: Objective　To investigate the expression and significance of decoy receptor（DcR3）in hepatitis B virus（HBV）e-antigen（HBeAg）negative chronic hepatitis B（CHB）patients. Methods　Serum DcR3 levels were measured by enzyme-linked immunosorbent assay（ELISA）in 80 HBeAg negative CHB patients and 96 healthy subjects. Alanine aminotransferase（ALT）was determined by automatic analyzer. Serum HBV DNA was determined by polymerase chain reaction（PCR). Results　DcR3 level in HBeAg negative CHB patients [1.58(0.48-3.23)ng/mL]was significantly higher than that in healthy controls [0.83(0.16-2.32）ng/mL，P＜0.000 1]. DcR3 level was correlated positively with HBV DNA （r＝0.704，P＜0.000 1）and ALT （r＝0.732，P＜0.000 1). Conclusions　DcR3 has high expression and correlates with HBV DNA and ALT in HBeAg negative CHB patients，and DcR3 may serve as a diagnosis and treatment monitoring indicator for HBeAg negative CHB patients.

Key words: Decoy receptor 3, Chronic hepatitis B, Alanine aminotransferase, DNA

侯彦强 1，梁冬雨 1，彭亮 1，娄晓丽 1，刘涛 1，张鲁榕 2. 诱骗受体3在HBeAg阴性的慢性乙型肝炎患者中的表达及意义[J]. 检验医学, 2013, 28(1): 37-39.

HOU Yanqiang 1，LIANG Dongyu 1，PENG Liang 1，LOU Xiaoli 1，LIU Tao 1，ZHANG Lurong 2. Expression and significance of decoy receptor 3 in HBeAg negative chronic hepatitis B patients[J]. , 2013, 28(1): 37-39.

诱骗受体3在HBeAg阴性的慢性乙型肝炎患者中的表达及意义

Expression and significance of decoy receptor 3 in HBeAg negative chronic hepatitis B patients

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