Application role of human gamma interferon-induced protein 16 in childhood infectious mononucleosis

doi:10.3969/j.issn.1673-8640.2021.09.004

Abstract

Abstract:

Objective To investigate the clinical application value of serum human gamma interferon-induced protein 16（IFI16） in childhood infectious mononucleosis（IM）. Methods A total of 73 children with IM（IM group）were recruited,of which 20 children with IM had acute phase and recovery phase. Totally,75 healthy children were enrolled as control group. White blood cell（WBC） count,the percentage of lymphocyte（LYMPH%）,the percentage of atypical lymphocyte,lymphocyte subsets and serum levels of IFI16 were determined. Pearson correlation analysis was used to analyze the correlations. Results WBC count,LYMPH%,the percentage of atypical lymphocyte and serum levels of IFI16 in IM group were higher than those in control group（P<0.01）. Serum level of IFI16 among IM children in recovery phase was higher than that in acute phase（P<0.05）. Serum level of IFI16 in IM group was positively correlated with LYMPH%,the percentage of CD4⁺ T cell and the ratio of CD4⁺/CD8⁺（r values were 0.24,0.27 and 0.29,respectively,P<0.05）. There was no correlation with the percentage of atypical lymphocyte,the percentage of CD3⁺ T cell,the percentage of CD8⁺ T cell,the percentage of CD19⁺ B cell and the CD16⁺CD56⁺natural killer cell（r values were -0.13,-0.18,-0.19,0.12 and 0.09,respectively,P>0.05）. Conclusions Serum level of IFI16 may be used for the auxiliary diagnosis and prognosis judgment of IM.

Key words: Interferon-induced protein 16, Infectious mononucleosis, Epstein-Barr virus

CLC Number:

R446.1

YU Lisha, YANG Huijie, YIN Xuerui, GE Hanyu, WANG Huiyan, ZHENG Xiaoqun. Application role of human gamma interferon-induced protein 16 in childhood infectious mononucleosis[J]. Laboratory Medicine, 2021, 36(9): 906-908.

Figures/Tables 2

References 10

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组别	例数	WBC计数/（×10⁹/L）	LYMPH%/%	异型淋巴细胞百分比/%	IFI16/（ng/L）
正常对照组	75	7.8±1.5	43.6±9.5	0±0	96.7（65.0~114.0）
IM组	73	16.2±5.2^*	54.6±8.9^*	12.1±6.4^*	121.6（58.0~267.0）^*

组别	例数	WBC计数/（×10⁹/L）	LYMPH%/%	异型淋巴细胞百分比/%	IFI16/（ng/L）
正常对照组	75	7.8±1.5	43.6±9.5	0±0	96.7（65.0~114.0）
IM组	73	16.2±5.2^*	54.6±8.9^*	12.1±6.4^*	121.6（58.0~267.0）^*

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