Abstract:

Objective To analyze the results of 3 Epstein-Barr virus（EBV） antibody combined determination,to evaluate the status of EBV infection among healthy subjects,and to provide a reference for the early screening of nasopharyngeal carcinoma. Methods A total of 4 251 healthy subjects from the Health Management Center of Beijing Aerospace General Hospital from January 1,2017 to June 30,2018 were enrolled. EBV Rta-IgG,viral capsid antigen（VCA）-IgA and early antigen（EA）-IgA antibodies were determined combinedly. The results were analyzed statistically by SPSS 16.0 software. Results Among the 4 251 healthy subjects,there was statistical significance in the single positive rates of 3 EBV antibodies（χ²=12.465,P=0.000）,and the positive rates were in the order of VCA-IgA,EA-IgA and Rta-IgG antibodies from high to low. The positive rate of VCA-IgA antibody in males was higher than that in females（P=0.000）. The overall positive rate of 3 EBV antibodies increased with ages. The positive rates of EA-IgA antibody（P=0.000） and Rta-IgG antibody（P=0.003 8） ad statistical significance in different age groups. The positive rates of EA-IgA and Rta-IgG antibodies were high in subjects ≥61 years old（6.3% and 3.7%,respectively）,and the positive rate of VCA-IgA antibody was the highest in subjects ≥51 years old. Among the subjects,92.9% were triple-negative,6.4% were single-positive,0.7% were double-positive,and no tirple-positive was found. The results of antibody positivity showed no difference in the aggregation of males and females,and the proportions of rhinitis,sinusitis and other abnormalities were higher in antibody positive group. Conclusions The positive rates of 3 EBV antibodies are related to sex and age. Subjects ≥50 years old should focus on EBV antibody screening. Nasopharyngoscopy should be recommended for patients with positive EBV antibodies,in order to provide a reference for the early screening of nasopharyngeal carcinoma.

Key words: Epstein-Barr virus antibody, Combined determination, Healthy subject