doi:10.3969/j.issn.1673-8640.2023.12.008

Abstract

CLC Number:

R446.1

Figures/Tables 4

References 13

[1]	BECK L H Jr, BONEGIO R G, LAMBEAU G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy[J]. N Engl J Med, 2009, 361(1):11-21. DOI URL
[2]	HOFSTRA J M, BECK L H J R, BECK D M, et al. Anti-phospholipase A receptor antibodies correlate with clinical status in idiopathic membranous nephropathy[J]. Clin J Am Soc Nephrol, 2011, 6(6):1286-1291. DOI URL
[3]	刘莎莎, 张丽, 李素华, 等. 血清抗磷脂酶A2受体抗体在特发性膜性肾病诊断中意义[J]. 中华实用诊断与治疗杂志, 2016, 30(4):405-406.
[4]	FLOEGE J, BARBOUR S J, CATTRAN D C, et al. Management and treatment of glomerular diseases(part 1) :conclusions from a kidney disease:improving global outcomes(KDIGO) controversies conference[J]. Kidney Int, 2019, 95(2):268-280. DOI URL
[5]	YY/T 1789.2-2021. 体外诊断检验系统性能评价方法第2部分:正确度[S].
[6]	YY/T 1789.3-2022. 体外诊断检验系统性能评价方法第3部分:检出限与定量限[S].
[7]	COUSER W G. Primary membranous nephropathy[J]. Clin J Am Soc Nephrol, 2017, 12(6):983-997. DOI URL
[8]	伍敏, 魏青, 刘必成. 原发性膜性肾病诊断及治疗新进展[J]. 中国实用内科杂志, 2023, 43(3):183-187.
[9]	VAN DE LOGT A E, FRESQUET M, WETZELS J F, et al. The anti-PLA2R antibody in membranous nephropathy:what we know and what remains a decade after its discovery[J]. Kidney Int, 2019, 96(6):1292-1302. DOI URL
[10]	CATTRAN D C, BRENCHLEY P E. Membranous nephropathy:integrating basic science into improved clinical management[J]. Kidney Int, 2017, 91(3):566-574. DOI URL
[11]	DE VRIESE A S, GLASSOCK R J, NATH K A, et al. A proposal for a serology-based approach to membranous nephropathy[J]. J Am Soc Nephrol, 2017, 28(2):421-430. DOI PMID
[12]	FRANCIS J M, BECK L H J R, SALANT D J. Membranous nephropathy:a journey from bench to bedside[J]. Am J Kidney Dis, 2016, 68(1):138-147. DOI URL
[13]	胡广. 血清抗PLA2R抗体在特发性膜性肾病诊断及病情评估中应用的可行性分析[D]. 南宁: 广西中医药大学, 2020.

样本	批内精密度					批间精密度
	CLIA			ELISA			CLIA			ELISA
		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %	$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %
低值	16.34	0.20	1.23	12.33	1.01	8.18	16.04	0.42	2.59	13.65	1.18	8.67
高值	1 082.32	15.69	1.45	1 053.55	89.66	8.51	1 077.98	22.85	2.12	1 056.20	94.11	8.91

样本	批内精密度					批间精密度
	CLIA			ELISA			CLIA			ELISA
		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %		$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %	$\bar{x}$/ （RU/mL）	s/（RU/mL）	CV/ %
低值	16.34	0.20	1.23	12.33	1.01	8.18	16.04	0.42	2.59	13.65	1.18	8.67
高值	1 082.32	15.69	1.45	1 053.55	89.66	8.51	1 077.98	22.85	2.12	1 056.20	94.11	8.91

ELISA	CLIA		合计
ELISA	阳性	阴性	合计
阳性	112	1	113
阴性	9	165	174
合计	121	166	287

ELISA	CLIA		合计
ELISA	阳性	阴性	合计
阳性	112	1	113
阴性	9	165	174
合计	121	166	287

组别	例数	CLIA/（RU/mL）	ELISA/（RU/mL）
PMN组	135	225.50±194.79	196.12±160.67
非PMN组	152	2.47±1.81	4.12±2.52
t值		6.06	2.46
P值		<0.01	<0.01

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 4

References 13

Related Articles 15

Recommended Articles

Metrics

[1]	ZHANG Lan, ZHU Jianfeng, PAN Baishen, CHEN Pu, WANG Beili, GUO Wei. Prognostic value of circulating plasma cells determined by morphology in newly diagnosed multiple myeloma [J]. Laboratory Medicine, 2025, 40(1): 15-19.
[2]	GUO Fengxia, HU Bing, SHA Yanhua. Role of methyltransferase-like protein 14 in patients with coronary heart disease [J]. Laboratory Medicine, 2025, 40(1): 54-58.
[3]	GAN Chenxin, CHEN Minghui, WANG Yajie, WU Jiaoxiang, FANG Fengqin, LIN Jinpiao, SHENG Huiming. Correlation between glycemic control and T cell memory subsets in type 2 diabetes mellitus patients [J]. Laboratory Medicine, 2025, 40(1): 59-65.
[4]	ZHANG Aimin, YIN Yue, QIN Li, ZHANG Na, WANG Chunyan, JIA Mei, PEI Lin. Correlation between serum sd-LDL-C，the severity of coronary heart disease and the risk of cardiovascular events in type 2 diabetes mellitus patients [J]. Laboratory Medicine, 2025, 40(1): 66-72.
[5]	LI Dezhong, WANG Zhiwei, XU Wenjuan, SHU Pinyuan. Serum suPAR and SDC4 levels in patients with severe bronchial asthma and their relationship with lung function and prognosis [J]. Laboratory Medicine, 2025, 40(1): 79-83.
[6]	WANG Chi, LIU Shaomei, LI Mianyang. Research progress on artificial intelligence in assisting diagnosis of bone marrow cell morphology [J]. Laboratory Medicine, 2025, 40(1): 8-14.
[7]	CHEN Dingzhong, YANG Wen, FENG Yanju, LIANG Xian, ZHANG Xiaozhen. Predictive value of combined determination of serum SFRP5 and KLK1 for myocardial no-reflow after PCI in patients with ST-segment elevation myocardial infarction [J]. Laboratory Medicine, 2025, 40(1): 84-89.
[8]	QIN Shuo, WANG Ying, LIU Li, XIONG Yi, TIAN Yong, WANG Xueqing, XIONG Yanwen, LI Shaoqiang, ZHOU Chengzhi, WANG Xiaoling, LIU Zhizhen. Field application evaluation of intelligent oropharyngeal swab sampling robot [J]. Laboratory Medicine, 2025, 40(1): 90-95.
[9]	MA Xinxin, LU Hongxiang, SHI Qinghai. Human phospholipid scramblase 1 in antiviral infection [J]. Laboratory Medicine, 2025, 40(1): 96-101.
[10]	Beijing Medical Association Laboratory Medicine Branch, Shanghai Medical Association Laboratory Medicine Branch. Expert consensus on interference factors and solutions for immunological testing [J]. Laboratory Medicine, 2024, 39(12): 1131-1139.
[11]	WANG Ziwen, WU Wenjuan. Research progress on determination and mechanism of drug resistance and tolerance to Cryptococcus neoformans [J]. Laboratory Medicine, 2024, 39(12): 1140-1144.
[12]	XU Chunhui, ZHOU Xinyue, YI Huiming, ZHANG Lining, CHEN Shulian, ZHU Guoqing, FENG Sizhou. Diagnostic roles of mNGS and Mucorales PCR in pulmonary mucormycosis in patients with blood diseases [J]. Laboratory Medicine, 2024, 39(12): 1145-1149.
[13]	LIU Ruiguang, GUO Jian. Hospital and external environmental fungal screening and drug susceptibility analysis [J]. Laboratory Medicine, 2024, 39(12): 1150-1156.
[14]	WANG Dongjiang, HU Liang, GUO Jian, LI Teng, TIAN Wenjie, YANG Simin, ZHANG Min, LIN Huiping, WAN Feifei, WANG Ziwen, ZHOU Aiping. Drug resistance in clinical isolates of Candida parapsilosis species complex in eastern China region from 2017 to 2023 [J]. Laboratory Medicine, 2024, 39(12): 1163-1168.
[15]	ZHU Xiaoyu, LI Zhiwei, JIA Jintong, LI Shuling, LIU Yezi, WANG Lingling, WANG Qian, LU Peipei, SHI Qinghai. Peripheral blood expressions of PD-1，LAG-3 and related cytokines in patients with acute and chronic brucellosis [J]. Laboratory Medicine, 2024, 39(12): 1173-1180.