Laboratory Medicine ›› 2022, Vol. 37 ›› Issue (1): 51-55.DOI: 10.3969/j.issn.1673-8640.2022.01.010
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XIONG Zhongbo, WANG Lei(), YIN Beiqi, DAI Yue, WEI Xiaoqing, LU Pei
Received:
2020-07-20
Revised:
2021-08-18
Online:
2022-01-30
Published:
2022-03-07
Contact:
WANG Lei
CLC Number:
XIONG Zhongbo, WANG Lei, YIN Beiqi, DAI Yue, WEI Xiaoqing, LU Pei. Clinical roles of SAA and CRP in pathological staging and metastasis of gastrointestinal cancer[J]. Laboratory Medicine, 2022, 37(1): 51-55.
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组别 | 例数 | SAA/(mg/L) | CRP/(mg/L) | CA242/(ng/mL) | |||
---|---|---|---|---|---|---|---|
正常对照组 | 104 | 5.52(3.72~8.54) | 4.65(2.50~12.10) | 2.32(1.11~3.60) | |||
息肉组 | 97 | 7.65(5.65~13.38) | 4.70(2.82~7.57) | 3.15(1.26~4.81) | |||
胃肠道肿瘤组 | 400 | 25.11(5.55~97.49)*# | 6.44(1.00~31.70)*# | 5.85(2.87~14.04)*# | |||
组别 | CA19-9/(U/mL) | CEA/(ng/mL) | CA50/(U/mL) | ||||
正常对照组 | 10.59(8.41~16.44) | 2.02(1.35~2.55) | 5.32(3.49~8.96) | ||||
息肉组 | 9.67(5.17~15.81) | 2.27(1.31~3.18) | 6.66(3.65~10.56) | ||||
胃肠道肿瘤组 | 13.29(6.03~34.18)*# | 3.29(1.77~10.80)*# | 11.67(5.74~27.65)*# |
组别 | 例数 | SAA/(mg/L) | CRP/(mg/L) | CA242/(ng/mL) | |||
---|---|---|---|---|---|---|---|
正常对照组 | 104 | 5.52(3.72~8.54) | 4.65(2.50~12.10) | 2.32(1.11~3.60) | |||
息肉组 | 97 | 7.65(5.65~13.38) | 4.70(2.82~7.57) | 3.15(1.26~4.81) | |||
胃肠道肿瘤组 | 400 | 25.11(5.55~97.49)*# | 6.44(1.00~31.70)*# | 5.85(2.87~14.04)*# | |||
组别 | CA19-9/(U/mL) | CEA/(ng/mL) | CA50/(U/mL) | ||||
正常对照组 | 10.59(8.41~16.44) | 2.02(1.35~2.55) | 5.32(3.49~8.96) | ||||
息肉组 | 9.67(5.17~15.81) | 2.27(1.31~3.18) | 6.66(3.65~10.56) | ||||
胃肠道肿瘤组 | 13.29(6.03~34.18)*# | 3.29(1.77~10.80)*# | 11.67(5.74~27.65)*# |
项目 | 例数 | SAA/(mg/L) | CRP/(mg/L) | CA242/(ng/mL) | |||
---|---|---|---|---|---|---|---|
TNM分期 | |||||||
Ⅰ~Ⅱ期 | 133 | 11.18(3.40~35.00) | 6.55(0.89~35.70) | 4.79(2.56~8.33) | |||
Ⅲ~Ⅳ期 | 149 | 62.06(8.59~170.00)* | 5.28(1.16~25.16) | 7.16(3.28~22.09)* | |||
T分期 | |||||||
T1~T2期 | 82 | 13.60(4.15~40.23) | 4.52(0.57~34.87) | 4.89(3.03~8.56) | |||
T3~T4期 | 200 | 29.97(6.18~121.25)# | 7.21(1.42~32.85) | 6.34(2.81~15.02)# | |||
N分期 | |||||||
N0期 | 132 | 10.96(3.40~36.33) | 5.93(0.93~35.70) | 4.88(2.70~8.33) | |||
N1~N2期 | 150 | 29.70(4.80~139.60)△ | 5.41(1.12~25.41) | 7.10(3.11~60.35)△ | |||
M分期 | |||||||
M0期 | 229 | 17.22(4.80~68.94) | 4.98(0.99~34.31) | 5.38(2.80~9.95) | |||
M1期 | 53 | 45.93(3.82~179.74) | 7.51(1.41~26.48) | 19.01(3.75~20.00)▲ | |||
项目 | CA19-9/(U/mL) | CEA/(ng/mL) | CA50/(U/mL) | ||||
TNM分期 | |||||||
Ⅰ~Ⅱ期 | 9.88(5.05~18.92) | 2.77(1.77~4.45) | 9.50(4.34~17.51) | ||||
Ⅲ~Ⅳ期 | 16.75(6.05~88.81)* | 4.69(1.92~16.82)* | 15.03(6.31~70.91)* | ||||
T分期 | |||||||
T1~T2期 | 11.92(4.81~17.61) | 2.90(1.77~5.06) | 10.88(4.50~17.36) | ||||
T3~T4期 | 14.39(6.00~42.81)# | 3.37(1.92~12.39) | 11.74(5.96~37.56)# | ||||
N分期 | |||||||
N0期 | 9.88(5.05~19.33) | 2.82(1.77~4.66) | 9.58(4.34~17.36) | ||||
N1~N2期 | 16.45(6.05~107.85)△ | 4.74(1.94~21.00)△ | 15.03(6.31~79.27)△ | ||||
M分期 | |||||||
M0期 | 11.40(5.72~21.98) | 2.90(1.77~6.75) | 10.12(5.23~19.63) | ||||
M1期 | 100.20(7.96~362.25)▲ | 14.75(2.77~39.54)▲ | 56.76(9.54~310.92)▲ |
项目 | 例数 | SAA/(mg/L) | CRP/(mg/L) | CA242/(ng/mL) | |||
---|---|---|---|---|---|---|---|
TNM分期 | |||||||
Ⅰ~Ⅱ期 | 133 | 11.18(3.40~35.00) | 6.55(0.89~35.70) | 4.79(2.56~8.33) | |||
Ⅲ~Ⅳ期 | 149 | 62.06(8.59~170.00)* | 5.28(1.16~25.16) | 7.16(3.28~22.09)* | |||
T分期 | |||||||
T1~T2期 | 82 | 13.60(4.15~40.23) | 4.52(0.57~34.87) | 4.89(3.03~8.56) | |||
T3~T4期 | 200 | 29.97(6.18~121.25)# | 7.21(1.42~32.85) | 6.34(2.81~15.02)# | |||
N分期 | |||||||
N0期 | 132 | 10.96(3.40~36.33) | 5.93(0.93~35.70) | 4.88(2.70~8.33) | |||
N1~N2期 | 150 | 29.70(4.80~139.60)△ | 5.41(1.12~25.41) | 7.10(3.11~60.35)△ | |||
M分期 | |||||||
M0期 | 229 | 17.22(4.80~68.94) | 4.98(0.99~34.31) | 5.38(2.80~9.95) | |||
M1期 | 53 | 45.93(3.82~179.74) | 7.51(1.41~26.48) | 19.01(3.75~20.00)▲ | |||
项目 | CA19-9/(U/mL) | CEA/(ng/mL) | CA50/(U/mL) | ||||
TNM分期 | |||||||
Ⅰ~Ⅱ期 | 9.88(5.05~18.92) | 2.77(1.77~4.45) | 9.50(4.34~17.51) | ||||
Ⅲ~Ⅳ期 | 16.75(6.05~88.81)* | 4.69(1.92~16.82)* | 15.03(6.31~70.91)* | ||||
T分期 | |||||||
T1~T2期 | 11.92(4.81~17.61) | 2.90(1.77~5.06) | 10.88(4.50~17.36) | ||||
T3~T4期 | 14.39(6.00~42.81)# | 3.37(1.92~12.39) | 11.74(5.96~37.56)# | ||||
N分期 | |||||||
N0期 | 9.88(5.05~19.33) | 2.82(1.77~4.66) | 9.58(4.34~17.36) | ||||
N1~N2期 | 16.45(6.05~107.85)△ | 4.74(1.94~21.00)△ | 15.03(6.31~79.27)△ | ||||
M分期 | |||||||
M0期 | 11.40(5.72~21.98) | 2.90(1.77~6.75) | 10.12(5.23~19.63) | ||||
M1期 | 100.20(7.96~362.25)▲ | 14.75(2.77~39.54)▲ | 56.76(9.54~310.92)▲ |
项目 | AUC(95%可信区间) | 最佳临界值 | 敏感性/% | 特异性/% | Youden指数 |
---|---|---|---|---|---|
SAA | 0.732(0.671~0.794) | 54.17 mg/L | 53.20 | 86.70 | 0.399 |
CRP | 0.505(0.429~0.574) | 25.13 mg/L | 24.70 | 66.70 | 0.086 |
CA242 | 0.626(0.556~0.695) | 11.35 ng/mL | 37.30 | 88.60 | 0.259 |
CA19-9 | 0.631(0.562~0.700) | 28.84 U/mL | 36.70 | 88.60 | 0.253 |
CEA | 0.604(0.532~0.675) | 10.38 ng/mL | 39.30 | 88.60 | 0.279 |
CA50 | 0.625(0.555~0.695) | 29.20 U/mL | 34.70 | 90.20 | 0.249 |
SAA+CRP+CA242 | 0.769(0.710~0.827) | 0.46 | 63.50 | 83.30 | 0.468 |
项目 | AUC(95%可信区间) | 最佳临界值 | 敏感性/% | 特异性/% | Youden指数 |
---|---|---|---|---|---|
SAA | 0.732(0.671~0.794) | 54.17 mg/L | 53.20 | 86.70 | 0.399 |
CRP | 0.505(0.429~0.574) | 25.13 mg/L | 24.70 | 66.70 | 0.086 |
CA242 | 0.626(0.556~0.695) | 11.35 ng/mL | 37.30 | 88.60 | 0.259 |
CA19-9 | 0.631(0.562~0.700) | 28.84 U/mL | 36.70 | 88.60 | 0.253 |
CEA | 0.604(0.532~0.675) | 10.38 ng/mL | 39.30 | 88.60 | 0.279 |
CA50 | 0.625(0.555~0.695) | 29.20 U/mL | 34.70 | 90.20 | 0.249 |
SAA+CRP+CA242 | 0.769(0.710~0.827) | 0.46 | 63.50 | 83.30 | 0.468 |
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