Research progress of non-invasive molecular biological methods for detecting Helicobacter pylori

doi:10.3969/j.issn.1673-8640.2021.08.021

Abstract

Abstract:

Helicobacter pylori is closely related to the occurrence of digestive system diseases,such as chronic active gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue（MALT） lymphoma and gastric cancer. It is currently the only pathogen that is classified as class Ⅰ carcinogen by World Health Organization. With the development of molecular biological technology,a variety of molecular biological methods for Helicobacter pylori identification,drug resistance and virulence analysis have emerged,which are of significance to the accurate diagnosis and treatment of Helicobacter pylori infection. The molecular biological methods of non-invasive detection of Helicobacter pylori from oral cavity or fecal samples directly have the advantages of simplicity,efficiency,economy and non-invasiveness,and have become a research hot-spot recently. This review will analyze and compare the pros and cons of various conventional methods for detecting Helicobacter pylori,focusing on the research progress of non-invasive molecular biological methods for detecting Helicobacter pylori.

Key words: Helicobacter pylori, Oral cavity sample, Fecal sample, Non-invasion, Molecular biological method, Detection

CLC Number:

R446.1

CHI Wenjing, LIU Tao, LIU Yixin, ZHAO Hu, ZHANG Yanmei. Research progress of non-invasive molecular biological methods for detecting Helicobacter pylori[J]. Laboratory Medicine, 2021, 36(8): 880-885.

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