Laboratory Medicine ›› 2021, Vol. 36 ›› Issue (7): 685-690.DOI: 10.3969/j.issn.1673-8640.2021.07.001
Received:
2021-04-26
Online:
2021-07-30
Published:
2021-07-26
CLC Number:
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2021.07.001
变化趋势 | 变化幅度 | SAA/ CRP比值 | 临床诊断建议 |
---|---|---|---|
SAA↑↑①、CRP↑② | 相似 | 小于正常对照 | 细菌感染可能性大 |
SAA↑↑、CRP→↑③ | SAA升高幅度显著大于CRP升高幅度 | 大于正常对照 | 病毒感染可能性大 |
变化趋势 | 变化幅度 | SAA/ CRP比值 | 临床诊断建议 |
---|---|---|---|
SAA↑↑①、CRP↑② | 相似 | 小于正常对照 | 细菌感染可能性大 |
SAA↑↑、CRP→↑③ | SAA升高幅度显著大于CRP升高幅度 | 大于正常对照 | 病毒感染可能性大 |
[1] | WHO. 儿童:降低死亡率[EB/OL]. ( 2018-09-19)[2021-02-01]. https://www.who.int/zh/news-room/fact-sheets/detail/children-reducing-mortality. |
[2] |
UNGER S A, BOGAERT D. The respiratory microbiome and respiratory infections[J]. J Infect, 2017, 74(Suppl 1):S84-S88.
DOI URL |
[3] |
MAHONY J B. Nucleic acid amplification-based diagnosis of respiratory virus infections[J]. Expert Rev Anti Infect Ther, 2010, 8(11):1273-1292.
DOI URL |
[4] | ROSENTHAL C J, FRANKLIN E C, FRANGIONE B, et al. Isolation and partial characterization of SAA-an amyloid-related protein from human serum[J]. J Immunol, 1976, 116(5):1415-1418. |
[5] |
URIELI-SHOVAL S, LINKE R P, MATZNER Y. Expression and function of serum amyloid A,a major acute-phase protein,in normal and disease states[J]. Curr Opin Hematol, 2000, 7(1):64-69.
DOI URL |
[6] | SACK G H Jr. Serum amyloid A(SAA) proteins[J]. Subcell Biochem, 2020, 94:421-436. |
[7] | CONNOLLY M, ROONEY P R, MCGARRY T, et al. Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms[J]. Ann Rheum Dis, 2016, 75(7):1392-1398. |
[8] |
YE R D, SUN L. Emerging functions of serum amyloid A in inflammation[J]. J Leukoc Biol, 2015, 98(6):923-929.
DOI URL |
[9] | YAMADA T. Serum amyloid A(SAA):a concise review of biology,assay methods and clinical usefulness[J]. Clin Chem Lab Med, 1999, 37(4):381-388. |
[10] |
GABAY C, KUSHNER I. Acute-phase proteins and other systemic responses to inflammation[J]. N Engl J Med, 1999, 340(6):448-454.
DOI URL |
[11] | 姜剑巍, 杨宇, 应春妹. 乳胶增强免疫散射比浊法检测血清淀粉样蛋白A的应用评价[J]. 检验医学, 2015, 30(1):49-52. |
[12] | 吕艳关, 赵玉杰, 林小飞. SAA、hs-CRP、IL-6联合检测在儿童感染性疾病中的诊断价值[J]. 国际检验医学杂志, 2020, 41(16):1935-1938. |
[13] |
MIWATA H, YAMADA T, OKADA M, et al. Serum amyloid A protein in acute viral infections[J]. Arch Dis Child, 1993, 68(2):210-214.
DOI URL |
[14] |
NAKAYAMA T, SONODA S, URANO T, et al. Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases[J]. Clin Chem, 1993, 39(2):293-297.
DOI URL |
[15] | DOWNES K J, WEISS S L, GERBER J S, et al. A pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit:the Optimizing Antibiotic Strategies in Sepsis(OASIS) Study[J]. J Pediatric Infect Dis Soc, 2017, 6(2):134-141. |
[16] | 秦中华, 宋晓梅, 杜岩青, 等. 血清SAA/CRP、CD64对儿童甲型流感早期诊断的临床价值分析[J]. 中国妇幼保健, 2020, 35(1):61-64. |
[17] | 廖嘉仪, 张涛. 血清淀粉样蛋白A联合C反应蛋白对儿童甲型流感早期诊断价值的评价[J]. 实用医学杂志, 2017, 33(14):2368-2370. |
[18] |
MIRAND A, PEIGUE-LAFEUILLE H. Clinical characteristics and course of hand,foot,and mouth disease[J]. Arch Pediatr, 2017, 24(10):1036-1046.
DOI URL |
[19] | FUJIMOTO T. Hand-foot-and-mouth disease,aseptic meningitis,and encephalitis caused by enterovirus[J]. Brain Nerve, 2018, 70(2):121-131. |
[20] |
LIN W, SU Y, JIANG M, et al. Clinical features for 89 deaths of hand,foot and mouth disease in Guangxi,China,2014[J]. Int J Infect Dis, 2017, 64:15-19.
DOI URL |
[21] | 赵昕峰, 吴亦栋, 高扬, 等. 血清淀粉样蛋白A联合C反应蛋白检测在手足口病患儿中的诊断价值[J]. 中华传染病杂志, 2016, 34(7):419-421. |
[22] |
LIU J, HUANG P, HE Y, et al. Serum amyloid A and clusterin as potential predictive biomarkers for severe hand,foot and mouth disease by 2D-DIGE proteomics analysis[J]. PLoS One, 2014, 9(9):e108816.
DOI URL |
[23] |
ZHOU F, CHEN X, CHEN G, et al. Identification of SAA and ACTB as potential biomarker of patients with severe HFMD using iTRAQ quantitative proteomics[J]. Clin Biochem, 2019, 67:1-6.
DOI URL |
[24] |
ARNON S, LITMANOVITZ I, REGEV R H, et al. Serum amyloid A:an early and accurate marker of neonatal early-onset sepsis[J]. J Perinatol, 2007, 27(5):297-302.
DOI URL |
[25] | HEDEGAARD S S, WISBORG K, HVAS A M. Diagnostic utility of biomarkers for neonatal sepsis-a systematic review[J]. Infect Dis(Lond), 2015, 47(3):117-124. |
[26] |
CETINKAYA M, OZKAN H, KÖKSAL N, et al. Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants[J]. J Perinatol, 2009, 29(3):225-231.
DOI URL |
[27] |
ENGUIX A, REY C, CONCHA A, et al. Comparison of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children[J]. Intensive Care Med, 2001, 27(1):211-215.
DOI URL |
[28] | WU F, HOU X Q, SUN R R, et al. The predictive value of joint detection of serum amyloid protein A,PCT,and Hs-CRP in the diagnosis and efficacy of neonatal septicemia[J]. Eur Rev Med Pharmacol Sci, 2019, 23(13):5904-5911. |
[29] |
NG P C, ANG I L, CHIU R W, et al. Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants[J]. J Clin Invest, 2010, 120(8):2989-3000.
DOI URL |
[30] | 查巍, 李林. SAA、CRP与WBC联合检测对儿童急性呼吸道细菌与肺炎支原体感染的鉴别诊断价值[J]. 安徽医学, 2020, 41(4):421-424. |
[31] | 高萍, 赵文姗, 高学松, 等. 儿童新型冠状病毒感染14例临床分析[J]. 中华全科医师杂志, 2020, 19(10):904-907. |
[32] | 王彬, 布学慧, 孔祥亘, 等. 成人37例与儿童10例新型冠状病毒肺炎的临床特点比较[J]. 山东大学学报(医学版), 2020, 58(10):112-116. |
[33] |
HUTTUNEN T, TEPPO A M, LUPISAN S, et al. Correlation between the severity of infectious diseases in children and the ratio of serum amyloid A protein and c-reactive protein[J]. Scand J Infect Dis, 2003, 35(8):488-490.
DOI URL |
[34] | DOS ANJOS B L, GROTTO H Z. Evaluation of c-reactive protein and serum amyloid A in the detection of inflammatory and infectious diseases in children[J]. Clin Chem Lab Med, 2010, 48(4):493-499. |
[35] | 罗国忠, 贺海文, 杨永成, 等. 血清淀粉样蛋白A和C-反应蛋白在小儿感染性疾病早期诊断中的价值[J]. 检验医学与临床, 2015, 12(22):3368-3370. |
[36] | 尹燕军, 袁宇峰, 肖羚, 等. 血清淀粉样蛋白A联合C反应蛋白检测在儿童消化道感染性疾病中的诊断价值[J]. 实验与检验医学, 2020, 38(4):725-727. |
[37] | 韩慧, 缪丽韶, 黄福达. WBC、CRP和SAA在儿童感染性疾病诊断中的价值[J]. 实验与检验医学, 2018, 36(3):355-357. |
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