doi:10.3969/j.issn.1673-8640.2020.10.027

Abstract

CLC Number:

R446.1

Figures/Tables 3

References 13

[1]	WEI M,YUAN J,LIU Y,et al.Novel coronavirus infection in hospitalized infants under 1 year of age in China[J]. JAMA,2020:323(13):1313-1314.
[2]	KAM K Q,YUNG C F,CUI L,et al.A well infant with coronavirus disease 2019(COVID-19) with high viral load[J]. Clin Infect Dis,2020,71(15):847-849.
[3]	ZHOU F,YU T,DU R,et al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan,China:a retrospective cohort study[J]. Lancet,2020,395(10229):1054-1062.
[4]	CHEN W,LAN Y,YUAN X,et al.Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity[J]. Emerg Microbes Infect,2020,9(1):469-473.
[5]	ZHANG W,DU R H,LI B,et al.Molecular and serological investigation of 2019-nCoV infected patients:implication of multiple shedding routes[J]. Emerg Microbes Infect,2020,9(1):386-389.
[6]	YANG X,YU Y,XU J,et al.Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan,China:a single-centered,retrospective,observational study[J]. Lancet Respir Med,2020,8(4):e26.
[7]	ZHAO D,YAO F,WANG L,et al.A comparative study on the clinical features of coronavirus 2019(COVID-19) pneumonia with other pneumonias[J]. Clin Infect Dis,2020,71(15):756-761.
[8]	LI L Q,HUANG T,WANG Y Q,et al.COVID-19 patients' clinical characteristics,discharge rate and fatality rate of meta-analysis[J]. J Med Virol,2020,92(6):577-583.
[9]	LI A M,NG P C.Severe acute respiratory syndrome(SARS) in neonates and children[J]. Arch Dis Child Fetal Neonatal Ed,2005,90(6):F461-F465.
[10]	HON K L,LEUNG C W,CHENG W T,et al.Clinical presentations and outcome of severe acute respiratory syndrome in children[J]. Lancet,2003,361(9370):1701-1703.
[11]	BITNUN A,ALLEN U,HEURTER H,et al.Children hospitalized with severe acute respiratory syndrome-related illness in Toronto[J]. Pediatrics,2003,112(4):e261.
[12]	SHEN K,YANG Y,WANG T,et al.Diagnosis,treatment,and prevention of 2019 novel coronavirus infection in children:experts' consensus statement[J]. World J Pediatr,2020,16(3):223-231.
[13]	CHAN J F,YUAN S,KOK K H,et al.A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission:a study of a family cluster[J]. Lancet,2020,395(10223):514-523.

时间	咽拭子样本		肛拭子样本		血清样本
时间	ORF基因CT值	N基因CT值	ORF基因CT值	N基因CT值	ORF基因CT值	N基因CT值
第1天	未检测到	未检测到
第3天	32.7	31.8
第13天	31	32	未检测到	未检测到	未检测到	未检测到
第16天	未检测到	未检测到	35.2	33.2
第19天	未检测到	38.4	36.8	32.4	未检测到	未检测到
第22天	未检测到	未检测到	36.8	36.8	未检测到	未检测到
第25天	未检测到	未检测到	未检测到	未检测到
第28天	未检测到	未检测到	未检测到	未检测到

时间	咽拭子样本		肛拭子样本		血清样本
时间	ORF基因CT值	N基因CT值	ORF基因CT值	N基因CT值	ORF基因CT值	N基因CT值
第1天	未检测到	未检测到
第3天	32.7	31.8
第13天	31	32	未检测到	未检测到	未检测到	未检测到
第16天	未检测到	未检测到	35.2	33.2
第19天	未检测到	38.4	36.8	32.4	未检测到	未检测到
第22天	未检测到	未检测到	36.8	36.8	未检测到	未检测到
第25天	未检测到	未检测到	未检测到	未检测到
第28天	未检测到	未检测到	未检测到	未检测到

日期	免疫层析法		胶体金法		酶联免疫法
日期	IgM	IgG	IgM	IgG	IgM	IgG
隔离第9天	+	+	+	+	0.293（+）	0.335（+）
隔离第15天	+	+	+	+	0.168（+）	0.411（+）
隔离第18天	-	+	-	+	0.061（-）	0.536（+）

日期	免疫层析法		胶体金法		酶联免疫法
日期	IgM	IgG	IgM	IgG	IgM	IgG
隔离第9天	+	+	+	+	0.293（+）	0.335（+）
隔离第15天	+	+	+	+	0.168（+）	0.411（+）
隔离第18天	-	+	-	+	0.061（-）	0.536（+）

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