Abstract:

Objective To analyze the characteristics of co-infection and drug susceptibility of group B Streptococcus（GBS） and Mycoplasma in perinatal women from 35 to 37 gestational weeks. Methods A total of 894 perinatal women from 35 to 37 gestational weeks in the People's Hospital of Xinjiang Uygur Autonomous Region from December 2017 to August 2018 were enrolled. Bacteria and fungi were determined by culture method. GBS was determined by broth enrichment culture automatic determination method,and Mycoplasma was determined by artificial culture method. Results In the 894 perinatal women,there were 65 cases of GBS infection and 41 cases of Ureaplasma urealyticum（Uu） infection,and there were 33 cases of co-infection. In bacterial infection（118 cases）,GBS was mainly,and in mixed infection（56 cases）,GBS+Uu was mainly. Totally,65 isolates of GBS were sensitive to linezolid,penicillin,vancomycin,meropenem,ampicillin and ceftriaxone,and the sensitive rates were 100%. The mediated isolates of levofloxacin,tetracycline and clindamycin were determined,and the drug resistance rate to clindamycin was the highest（86.15%）. Totally,41 isolates of Uu were sensitive to minocycline,doxycycline,roxithromycin,josamycin,and the sensitive rates were 100%. The mediated isolates of ciprofloxacin,sparfloxacin,ofloxacin,azithromycin,spectinomycin,levofloxacin and norfloxacin were determined,and the drug resistance rate to ciprofloxacin was the highest（92.68%）. Conclusions There are many infections of GBS and Uu in perinatal women in the People's Hospital of Xinjiang Uygur Autonomous Region,and the 2 infections are common. The drug resistance rate of GBS to clindamycin is high,and the drug resistance of Uu to ciprofloxacin is serious. Those should be taken seriously.

Key words: Perinatal stage, Group B Streptococcus, Mycoplasma, Co-infection, Drug susceptibility